Heartleaf Hyaluron Soothing Cream
What it's good for
Key actives from our research database. Click any to read the full evidence dossier.
A calming K-beauty botanical that's also antibacterial, so it pairs well for acne-prone, sensitive skin.
Good for: Anti-inflammatory, Anti-acne
A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.
Good for: Hydrating
Also called "cica," it calms redness, repairs the skin barrier, and speeds up recovery. The go-to for irritated or reactive skin.
Good for: Anti-inflammatory, Barrier repair
Refills the natural barrier between your skin cells. Locks moisture in, keeps irritants out, calms dry or damaged skin.
Good for: Barrier repair
Pro-vitamin B5. Deeply hydrates and helps repair the skin barrier, calming dry or compromised skin.
Good for: Hydrating, Barrier repair
A gentle smoother and skin-soother. Reduces flakiness and helps the surface look more even.
Good for: Anti-inflammatory, Hydrating
A heavy-duty hydrator that also reduces irritation. Often called "better than hyaluronic acid" for sensitive skin.
Good for: Hydrating, Anti-inflammatory
Evidence behind the ingredients
Real citations from our research database, one per tracked active in this product. Click any ingredient name to read its full evidence dossier.
A calming K-beauty botanical that's also antibacterial, so it pairs well for acne-prone, sensitive skin.
Song Z et al., Inhibition of LPS-Induced Skin Inflammatory Response and Barrier Damage via MAPK/NF-kB Signaling Pathway by Houttuynia cordata Thunb Fermentation Broth, Foods 2024
Kwon N et al., Protective Effects of Fermented Houttuynia cordata Against UVA and H2O2-Induced Oxidative Stress in Human Skin Keratinocytes, Applied Biochemistry and Biotechnology 2023;195(5):3027-3046 — Korean-authored; fermented H. cordata showed antioxidant and anti-inflammatory protection against UVA/H2O2 stress
Rafiq S et al., Pharmacological Effects of Houttuynia cordata Thunb (H. cordata): A Comprehensive Review, Pharmaceuticals (Basel) 2022
A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.
Karabat MU, Tuncer MC. Effects of hyaluronic acid on skin at the cellular level: a systematic review. Rev Assoc Med Bras. 2025;71(8):e20250208. — Systematic review of 45 studies found low-molecular-weight HA stimulates keratinocyte proliferation and migration while high-molecular-weight HA drives skin hydration, supporting topical HA as an effective skin-hydrating and barrier-supporting ingredient.
Bravo B et al., Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence, Dermatology and Therapy 2022;12(12):2657-2680 — HA-based cosmeceuticals reliably improve hydration and signs of skin aging
Lee SG et al., Hyaluronan Oligosaccharides Improve Rosacea-Like Phenotype through Anti-Inflammatory and Epidermal Barrier-Improving Effects, Annals of Dermatology 2020
Also called "cica," it calms redness, repairs the skin barrier, and speeds up recovery. The go-to for irritated or reactive skin.
Hur N et al., A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women, Nutrients 2026
Borowicz KK et al., Geroprotective Potential of Centella asiatica: Modulation of Cellular Aging, Nutrients 2026
Witkowska K et al., Topical Application of Centella asiatica in Wound Healing: Recent Insights into Mechanisms and Clinical Efficacy, Pharmaceutics 2024;16(10):1252 — modern hydrogel and nanostructured Centella delivery systems accelerate wound healing across wound types
+−4 more ingredients
Refills the natural barrier between your skin cells. Locks moisture in, keeps irritants out, calms dry or damaged skin.
Andrew PV et al., Topical supplementation with physiological lipids rebalances the stratum corneum ceramide profile and strengthens skin barrier function in adults predisposed to atopic dermatitis, British Journal of Dermatology 2025;193(4):729-740 — physiological-lipid emulsion raised SC ceramide NP/AP and improved barrier function vs control
Nugroho WT, Sawitri, Astindari, Utomo B, Listiawan MY, Ervianti E, Astari L. The Efficacy of Moisturisers Containing Ceramide Compared with Other Moisturisers in the Management of Atopic Dermatitis: A Systematic Literature Review and Meta-Analysis. Indian J Dermatol. 2023;68(1):53-58. — Meta-analysis of 5 studies found ceramide-containing moisturisers produced significantly greater improvement in SCORAD compared with non-ceramide moisturisers in atopic dermatitis.
Shindo S et al., Effects of a moisturizer containing pseudo-ceramide and a eucalyptus extract on sweating function in adult atopic dermatitis: a double-blind, randomized, controlled left-right comparison clinical trial, Journal of Cosmetic Dermatology 2022;21(10):4503-4509 — pseudo-ceramide + eucalyptus moisturizer restored sweating function and barrier in AD adults
Pro-vitamin B5. Deeply hydrates and helps repair the skin barrier, calming dry or compromised skin.
Gao Y et al., Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment, Journal of Cosmetic Dermatology 2025;24(7):e70223 — double-blind RCT (n=60): panthenol mask decreased erythema, enhanced hydration, repaired barrier vs saline
Cho YS et al., Use of Dexpanthenol for Atopic Dermatitis-Benefits and Recommendations Based on Current Evidence, Journal of Clinical Medicine 2022;11(14):3943 — Korean-authored review; dexpanthenol improves barrier and reduces severity in mild-to-moderate AD
Heise R et al., Accelerated wound healing with a dexpanthenol-containing ointment after fractional ablative CO2 laser resurfacing of photo-damaged skin in a randomized prospective clinical trial, Cutaneous and Ocular Toxicology 2019;38(3):274-278 — RCT: dexpanthenol significantly faster wound closure vs petroleum jelly post-laser
A gentle smoother and skin-soother. Reduces flakiness and helps the surface look more even.
Xu Z et al., Efficacy and Safety of Topical Compound Heparin Sodium Allantoin Gel for the Treatment of Rosacea, Journal of Cosmetic Dermatology 2025;24(4):e70129 — RCT (n=82, 12 weeks): allantoin gel improved erythema and alleviated itching/burning vs traditional therapy
Tan C et al., The combination of allantoin, bisabolol, D-panthenol and dipotassium glycyrrhizinate mitigates UVB-induced PGE2 synthesis by keratinocytes, International Journal of Cosmetic Science 2024;46(5):691-701 — in vitro: allantoin combination reduced UVB-induced PGE2, IL-1α, IL-6, IL-8, TNFα
Saucedo-Acuna RA et al. (Mexico), Characterization and In Vivo Assay of Allantoin-Enriched Pectin Hydrogel for the Treatment of Skin Wounds, International Journal of Molecular Sciences 2023;24(8):7377 — allantoin-pectin hydrogel reduced wound healing time by ~71% with complete closure at day 15 in rat model
A heavy-duty hydrator that also reduces irritation. Often called "better than hyaluronic acid" for sensitive skin.
Feng X et al., Exploring the Properties and Application Potential of beta-Glucan in Skin Care, Food Science and Nutrition 2025;13(4):e70212 — review concludes beta-glucan exhibits antioxidant, anti-inflammatory, barrier repair, and moisturizing bioactivities
Kussie HC et al., Avenanthramide and beta-Glucan Therapeutics Accelerate Wound Healing Via Distinct and Nonoverlapping Mechanisms, Advances in Wound Care 2024;13(4):155-166 — in vivo: beta-glucan accelerated wound closure with increased angiogenesis
Cao Y et al., Improving the outcome of treating striae gravidarum by combined therapies using topical β-glucan and 1565-nm non-ablative fractional laser, Journal of Dermatology 2022;49(9):829-836 — RCT; topical beta-glucan twice daily for 12 weeks on stretch marks
Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.
Full ingredient list
Everything on the package label, not just the tracked actives above.
- Contains fragrance: Eucalyptus Globulus Leaf OilWorth knowing if you have sensitive or reactive skin.
- Contains silicones: Vinyl Dimethicone, Caprylyl MethiconeNo irritancy evidence. CIR rates this safe as used; some shoppers avoid it by preference.
+−Show all 46 ingredients
Listed in the order printed on the package. By regulation, ingredients at 1% or higher are listed in descending order by concentration, so the first entry is the largest part of the formula.
- Water
- Glycerin
- Vinyl Dimethicone
- Butylene Glycol
- Caprylyl Methicone
- Dipropylene Glycol
- 1,2-Hexanediol
- Pentylene Glycol
- Erythritol
- Xylitol
- Houttuynia Cordata Extract (6,501Ppm)
- Saccharomyces Ferment Filtrate
- Sodium Hyaluronate (102.1Ppm)
- Chamaecyparis Obtusa Oil
- Eucalyptus Globulus Leaf Oil
- Hydrolyzed Hyaluronic Acid (0.15Ppm)
- Hyaluronic Acid (0.1Ppm)
- Candida Bombicola/Glucose/Methyl Rapeseedate Ferment
- Vitis Vinifera (Grape) Seed Oil
- Centella Asiatica Leaf Extract
- Chrysanthemum Zawadskii Extract
- Helianthus Annuus (Sunflower) Seed Oil
- Portulaca Oleracea Extract
- Ethylhexyl Palmitate
- Ammonium Acryloyldimethyltaurate/VP Copolymer
- Sorbitol
- Tromethamine
- Acrylates/C10-30 Alkyl Acrylate Crosspolymer
- Caprylic/Capric Triglyceride
- Ethylhexylglycerin
- Panthenol
- Hydrogenated Lecithin
- Sodium Phytate
- Ceramide NP
- Beta-Glucan
- Albatrellus Confluens (Mushroom) Extract
- Ectoin
- Cellulose
- Polyglutamic Acid
- Hyaluronic Acid/Polyisopropylacrylamide Copolymer (1Ppm)
- Glyceryl Caprylate
- Dimethylsilanol Hyaluronate (0.15Ppm)
- Hydrolyzed Sodium Hyaluronate (0.15Ppm)
- Potassium Hyaluronate (0.1Ppm)
- Tocopherol
- Hydroxypropyltrimonium Hyaluronate
Similar comparisons
Not medical advice. GlowPal is educational. Patch-test new products and talk to a qualified healthcare professional before changing your routine, especially if you're pregnant, nursing, or have a diagnosed skin condition. See our terms.