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Methodology

How we evaluate evidence.

645 citations across 10 databases, each one a specific source you can check. We grade every study by what it actually found, then sort the evidence into tiers. Below is the framework, the source list, and the rules we follow.

What our citations show

378
Positive efficacy

Single trials or meta-analyses concluding the ingredient works clinically.

43
Safety / regulatory

Cosmetic Ingredient Review (CIR), Scientific Committee on Consumer Safety (SCCS), or Korean Ministry of Food and Drug Safety (MFDS) documents. Safe to use at typical concentrations.

204
Mechanism only

Shows how the ingredient works in lab tests (in vitro), not proof it works on real skin.

20
Mixed / inconclusive

Reviews that explicitly say "trials needed" or "benefit unclear". We list them honestly.

We cite specific papers for all 129 ingredients we track.

Strong
15+ studies or large cohort

Multiple randomized controlled trials (RCTs), a systematic review, or a large longitudinal cohort. Mechanism confirmed at molecular level. Effect size meaningful at typical concentrations. (In-vitro / lab-only mechanism studies do not alone qualify an ingredient for Strong tier: human clinical data or regulatory approval is required.)

Moderate
5–14 studies

Several controlled trials, but smaller samples or mixed results. Mechanism plausible and partially confirmed.

Anecdotal
No clinical proof yet

Used in tradition or reported anecdotally to help, but we don't yet have controlled clinical evidence. May work for some people; we track these as the research catches up.

Beyond Count: The Concentration Gate

While an ingredient might have 50+ studies (Strong Tier), it only works if it's present in the product at the correct concentration. Korean Pharmacists (Yaksa) frequently highlight that many "cosmetic" products use trace amounts ("fairy dust") for marketing, while "Clinical Grade" products meet the specific PPM (Parts Per Million) thresholds proven in clinical papers.

Products with the ✨ badge have either disclosed concentration matching clinical papers or have been verified as pharmacy-grade staples.

Our 10 sources

We pull from databases that cover skincare research and regulators worldwide, well beyond Western dermatology. Each name links to the underlying database or regulator's own site (645 citations, primarily from PubMed (630) plus 9 additional regulatory and regional databases including KCI, Cochrane, and MFDS):

🌐
PubMed
US National Library of Medicine, the biomedical literature index
630
🌐
Cochrane
Independent systematic reviews of clinical evidence
6
🇰🇷
KCI
Korea’s national index of peer-reviewed academic journals
12
🇰🇷
KoreaMed
Korean medical journal aggregator that indexes Annals of Dermatology
5
🇯🇵
J-Stage
Japan’s national database of scientific & medical journals
4
🇨🇳
VIP
Chinese scientific journals with medical and dermatology coverage
3
🇫🇷
SFD
French dermatology society, publisher of Annales de Dermatologie et de Vénéréologie
4
🇰🇷
MFDS
Korean regulator that approves cosmetic functional actives
5
🇪🇺
SCCS
EU regulator’s cosmetic-safety panel, with opinions on actives + restrictions
6
🇺🇸
CIR
Independent US cosmetic-ingredient safety review panel
4

Counts grow as we add citations on a rolling basis. Every database listed here has at least one specific citation behind it; we do not count a source until it does. Chinese (Chongqing VIP) and French (SFD / Annales de Dermatologie) coverage is in active expansion for K-beauty botanicals and pigment-correction research.

How an ingredient gets in the database

  1. Two editors independently identify candidate ingredients from journal scans + reader requests.
  2. We pull every relevant citation (RCTs, in-vitro, in-vivo) and tag by study quality.
  3. An ingredient needs at least 3 peer-reviewed sourcesacross at least two databases before it's added.
  4. Tier is assigned by total study count + presence of RCTs + mechanism confirmation.
  5. Every claim on every page must link back to one of the cited papers. No exceptions.

How tiers can change

An emerging ingredient moves to "moderate" once it crosses 5 peer-reviewed studies including at least one controlled trial. Moderate moves to "strong" when one of two thresholds is met: 15+ studies including multiple RCTs, or a single large longitudinal cohort study (something like 50+ subjects followed for 12+ months with controlled measurement against baseline). One solid real-world cohort can carry as much weight as a stack of small trials when the methodology is sound. We re-review every ingredient in the database quarterly.

What we don't do

  • We don't accept industry-funded studies as the sole source for a tier upgrade.
  • We don't cite blogs, Reddit threads, or product marketing pages.
  • We don't cite an LLM as a source. Ever.
  • We don't let affiliate revenue influence recommendations. When you buy through a product link, we earn a small commission from the retailer (the price to you is identical). That relationship never changes which ingredients we recommend or how products are ranked. Full disclosure.