Ingredients Anti-inflammatory Heartleaf
31He
Sourced from heartleaf
Tier · Moderate evidence
Anti-inflammatory · Anti-acne

Heartleaf

INCI: Houttuynia Cordata Extract · Also called: Eo Seong Cho, Fish Mint

A calming K-beauty botanical that's also antibacterial, so it pairs well for acne-prone, sensitive skin.

For your skin

A calming K-beauty botanical that's also antibacterial, so it pairs well for acne-prone, sensitive skin.

Want the science? Keep reading ↓

Mechanism of action

Quercetin-rich botanical with antimicrobial and anti-inflammatory effects useful in acne-prone skin.

Why we tier this moderate

7 cited papers across 4 countries. The mechanism is well-described and there's at least one controlled trial in the literature, but we tier this Moderate rather than Strong to stay honest about how many specific papers we cite directly.

2
China
2
Korea
2
International
1
Japan

Layering matrix

Cited research

🇨🇳

Huang R et al., Houttuynia cordata polysaccharides ameliorate atopic dermatitis in mice through modulation of skin immune barrier and lipid metabolism, International Journal of Biological Macromolecules 2025;314:144264 — South-Central Minzu U Wuhan; HCP restored lipid metabolic homeostasis and modulated inflammation in AD mice

2025Mechanism onlyPMID:40393586View source ↗
🇰🇷

Kwon N et al., Protective Effects of Fermented Houttuynia cordata Against UVA and H2O2-Induced Oxidative Stress in Human Skin Keratinocytes, Applied Biochemistry and Biotechnology 2023;195(5):3027-3046 — Korean-authored; fermented H. cordata showed antioxidant and anti-inflammatory protection against UVA/H2O2 stress

2023Mechanism onlyPMID:36495375View source ↗
🇨🇳

Wu Z et al., Houttuynia cordata Thunb: An Ethnopharmacological Review, Frontiers in Pharmacology 2021;12:714694 — anti-inflammatory, antibacterial, antiviral effects supporting topical applications

2021Mechanism onlyPMID:34539401View source ↗
🌐

Mapoung S et al., Photoprotective Effects of a Hyperoside-Enriched Fraction Prepared from Houttuynia cordata Thunb. on Ultraviolet B-Induced Skin Aging in Human Fibroblasts through the MAPK Signaling Pathway, Plants 2021;10(12):2628 — hyperoside-enriched H. cordata protected fibroblasts from UVB-induced collagen breakdown

2021Mechanism onlyPMID:34961096View source ↗
🌐

Shingnaisui K et al., Therapeutic potentials of Houttuynia cordata Thunb. against inflammation and oxidative stress: A review, Journal of Ethnopharmacology 2018;220:35-43 — H. cordata extracts possess anti-inflammatory and antioxidant properties with no demonstrated toxicity

2018Mechanism onlyPMID:29605674View source ↗
🇯🇵

Anti-bacterial and anti-inflammatory effects of ethanol extract from Houttuynia cordata poultice, Bioscience, Biotechnology, and Biochemistry 2016 — in-vitro mechanism; no human controlled trial for skin to date. (Published in a Japanese journal: BBB is the official journal of the Japan Society for Bioscience, Biotechnology, and Agrochemistry; J-Stage-indexed.)

2016Mechanism onlyPMID:27023331View source ↗
🇰🇷

Xue Mei Li et al., Stimulation of keratinocyte differentiation by extract of combined medicinal plant, Journal of Biomedical and Translational Research 2014;15(4):176-181 — Heartleaf Houttuynia was 1 of 4 plant components in a combined extract (ECMP, alongside Taraxacum, Glycyrrhiza, and Ulmus davidiana). The combined extract induced keratinocyte differentiation markers (involucrin, loricrin, filaggrin) and accelerated TEWL recovery in tape-stripped mouse skin. The observed effect cannot be attributed to Heartleaf alone.

2014Positive — efficacyKCI:ART001951986View source ↗

Sources: PubMed · KCI · J-Stage · CNKI · Wanfang · SFD · MFDS · Cochrane · SCCS · CIR. Every entry points to a specific document. See methodology for what each outcome label means.