Ingredients Barrier repair Ceramides
14Ce
Sourced from rice, grain + lab
Tier · Strong evidence
Barrier repair

Ceramides

INCI: Ceramide NP · Also called: Ceramide 3, Ceramide AP, Ceramide EOP

Refills the natural barrier between your skin cells. Locks moisture in, keeps irritants out, calms dry or damaged skin.

For your skin

Refills the natural barrier between your skin cells. Locks moisture in, keeps irritants out, calms dry or damaged skin.

Want the science? Keep reading ↓

Mechanism of action

Lipid components of the skin barrier; replenish intercellular mortar to reduce water loss.

Why we tier this strong

6 cited papers across 3 countries. Multiple positive efficacy results plus regulatory backing. Clears our published bar (Strong = 15+ studies with multiple randomized controlled trials (RCTs), or a single large longitudinal cohort).

4
Japan
1
International
1
China

Layering matrix

Read the research

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Cited research

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Andrew PV et al., Topical supplementation with physiological lipids rebalances the stratum corneum ceramide profile and strengthens skin barrier function in adults predisposed to atopic dermatitis, British Journal of Dermatology 2025;193(4):729-740 — physiological-lipid emulsion raised SC ceramide NP/AP and improved barrier function vs control

2025Positive — efficacyPMID:40408261View source ↗
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Kawamoto A et al., Chain length of covalently bound ceramides correlates with skin barrier function in healthy subjects, Journal of Dermatological Science 2023;110(1):35-38 — clinical study: SC ceramide chain length directly correlates with barrier function; longer-chain ceramides are the functionally relevant species

2023Mechanism onlyPMID:37002180View source ↗
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Shindo S et al., Effects of a moisturizer containing pseudo-ceramide and a eucalyptus extract on sweating function in adult atopic dermatitis: a double-blind, randomized, controlled left-right comparison clinical trial, Journal of Cosmetic Dermatology 2022;21(10):4503-4509 — pseudo-ceramide + eucalyptus moisturizer restored sweating function and barrier in AD adults

2022Positive — efficacyPMID:35298858View source ↗
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Li Q et al., The role of ceramides in skin homeostasis and inflammatory skin diseases, Journal of Dermatological Science 2020;97(1):2-8 — abnormal ceramide levels contribute to barrier dysfunction; therapeutic target for atopic dermatitis and psoriasis

2020Mechanism onlyPMID:31866207View source ↗
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Fukunaga S et al., Effect of Torula Yeast (Candida utilis)-Derived Glucosylceramide on Skin Dryness and Other Skin Conditions in Winter, Journal of Nutritional Science and Vitaminology 2018;64(4):265-270 — randomized double-blind crossover (n=17): 1.8 mg/day oral torula-yeast glucosylceramide for 4 weeks decreased TEWL (p=0.01), reduced brown spots and chapped skin vs placebo. NOTE: oral, not topical

2018Positive — efficacyJSTAGE:jnsv-64-4-265View source ↗
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Ma L et al., Prolonging time to flare in pediatric atopic dermatitis: a randomized, investigator-blinded, controlled, multicenter clinical study of a ceramide-containing moisturizer, Advances in Therapy 2017;34(12):2601-2611 — median time to AD flare delayed from 27 to 89 days vs control

2017Positive — efficacyPMID:29143926View source ↗

Sources: PubMed · KCI · J-Stage · CNKI · Wanfang · SFD · MFDS · Cochrane · SCCS · CIR. Every entry points to a specific document. See methodology for what each outcome label means.