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Ingredients Hydrating Hyaluronic Acid
13HA
Sourced from microbe + lab
Tier · Strong evidence
Hydrating

Hyaluronic Acid

INCI: Sodium Hyaluronate · Also called: HA, Hyaluronan

A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.

For your skin

A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.

Want the science? Keep reading ↓

Mechanism of action

Polysaccharide humectant that binds up to 1000x its weight in water within the stratum corneum.

Why we tier this strong

7 cited papers across 3 countries. Multiple positive efficacy results plus regulatory backing. Our catalog highlights 7 cited papers as direct references, a curated sample from the broader body of published research that earns Hyaluronic Acid its Strong tier (15+ studies including multiple RCTs or a large longitudinal cohort). See our methodology for how we evaluate evidence.

3
International
2
Korea
2
United States

Layering matrix

Read the research

Compare with

Cited research

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Karabat MU, Tuncer MC. Effects of hyaluronic acid on skin at the cellular level: a systematic review. Rev Assoc Med Bras. 2025;71(8):e20250208. — Systematic review of 45 studies found low-molecular-weight HA stimulates keratinocyte proliferation and migration while high-molecular-weight HA drives skin hydration, supporting topical HA as an effective skin-hydrating and barrier-supporting ingredient.

2025Meta-analysis (positive)PMID:40990743View source ↗
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Bravo B et al., Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence, Dermatology and Therapy 2022;12(12):2657-2680 — HA-based cosmeceuticals reliably improve hydration and signs of skin aging

2022Meta-analysis (positive)PMID:36200921View source ↗
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Lee SG et al., Hyaluronan Oligosaccharides Improve Rosacea-Like Phenotype through Anti-Inflammatory and Epidermal Barrier-Improving Effects, Annals of Dermatology 2020

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An JH et al., Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin, Annals of Dermatology 2019;31(3):263-271 — cross-linked HA microneedle patches improved wrinkles on Korean skin with minimal discomfort

2019Positive (efficacy)PMID:33911590View source ↗
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Jegasothy SM et al., Efficacy of a New Topical Nano-hyaluronic Acid in Humans, Journal of Clinical and Aesthetic Dermatology 2014;7(3):27-29 — nano-HA produced up to 40% wrinkle-depth reduction, 96% hydration increase, and 55% elasticity improvement over 8 weeks

2014Positive (efficacy)PMID:24688623View source ↗
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Papakonstantinou E et al., Hyaluronic acid: A key molecule in skin aging, Dermato-Endocrinology 2012;4(3):253-8 — mechanism review (not a clinical efficacy claim)

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Pavicic T et al., Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment, Journal of Drugs in Dermatology 2011;10(9):990-1000 — low-MW HA significantly reduced wrinkle depth, all formulations improved hydration and elasticity

2011Positive (efficacy)PMID:22052267View source ↗

Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.