For your skin
Pro-vitamin B5. Deeply hydrates and helps repair the skin barrier, calming dry or compromised skin.
Want the science? Keep reading ↓Mechanism of action
Converts to pantothenic acid in skin; humectant and accelerates barrier repair.
Why we tier this moderate
5 cited papers across 4 countries. The mechanism is well-described and there's at least one controlled trial in the literature, but we tier this Moderate rather than Strong to stay honest about how many specific papers we cite directly.
Layering matrix
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Cited research
Gao Y et al., Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment, Journal of Cosmetic Dermatology 2025;24(7):e70223 — double-blind RCT (n=60): panthenol mask decreased erythema, enhanced hydration, repaired barrier vs saline
Cho YS et al., Use of Dexpanthenol for Atopic Dermatitis-Benefits and Recommendations Based on Current Evidence, Journal of Clinical Medicine 2022;11(14):3943 — Korean-authored review; dexpanthenol improves barrier and reduces severity in mild-to-moderate AD
Heise R et al., Accelerated wound healing with a dexpanthenol-containing ointment after fractional ablative CO2 laser resurfacing of photo-damaged skin in a randomized prospective clinical trial, Cutaneous and Ocular Toxicology 2019;38(3):274-278 — RCT: dexpanthenol significantly faster wound closure vs petroleum jelly post-laser
Proksch E et al., Topical use of dexpanthenol: a 70th anniversary article, Journal of Dermatological Treatment 2017;28(8):766-773 — dexpanthenol improves stratum-corneum hydration, barrier function, and wound healing
Biro K et al., Efficacy of dexpanthenol in skin protection against irritation: a double-blind, placebo-controlled study, Contact Dermatitis 2003;49(2):80-4 — corneometry significantly favored dexpanthenol vs placebo against SLS-induced irritation
Sources: PubMed · KCI · J-Stage · CNKI · Wanfang · SFD · MFDS · Cochrane · SCCS · CIR. Every entry points to a specific document. See methodology for what each outcome label means.