345 Relief Cream Daily Face Moisturizer with PDRN & Niacinamide (1.69 fl oz)
Tracked ingredients
Key actives from our research database. Click any to read the full evidence dossier.
Evidence behind the ingredients
Real citations from our research database — one per tracked active in this product. Click any ingredient name to read its full evidence dossier.
A calming K-beauty botanical that's also antibacterial, so it pairs well for acne-prone, sensitive skin.
Huang R et al., Houttuynia cordata polysaccharides ameliorate atopic dermatitis in mice through modulation of skin immune barrier and lipid metabolism, International Journal of Biological Macromolecules 2025;314:144264 — South-Central Minzu U Wuhan; HCP restored lipid metabolic homeostasis and modulated inflammation in AD mice
Song Z et al., Inhibition of LPS-Induced Skin Inflammatory Response and Barrier Damage via MAPK/NF-kB Signaling Pathway by Houttuynia cordata Thunb Fermentation Broth, Foods 2024
Kwon N et al., Protective Effects of Fermented Houttuynia cordata Against UVA and H2O2-Induced Oxidative Stress in Human Skin Keratinocytes, Applied Biochemistry and Biotechnology 2023;195(5):3027-3046 — Korean-authored; fermented H. cordata showed antioxidant and anti-inflammatory protection against UVA/H2O2 stress
A heavy-duty hydrator that also reduces irritation. Often called "better than hyaluronic acid" for sensitive skin.
Feng X et al., Exploring the Properties and Application Potential of beta-Glucan in Skin Care, Food Science and Nutrition 2025;13(4):e70212 — review concludes beta-glucan exhibits antioxidant, anti-inflammatory, barrier repair, and moisturizing bioactivities
Kussie HC et al., Avenanthramide and beta-Glucan Therapeutics Accelerate Wound Healing Via Distinct and Nonoverlapping Mechanisms, Advances in Wound Care 2024;13(4):155-166 — in vivo: beta-glucan accelerated wound closure with increased angiogenesis
Du B et al., Oat β-glucan ameliorates epidermal barrier disruption by upregulating CaSR via dectin-1-mediated ERK/p38 signaling, International Journal of Biological Macromolecules 2021 — mechanism for barrier-repair effects; in-vitro and animal-model evidence
A grape-derived antioxidant that defends skin from daily oxidative damage and helps even out tone. Often paired with vitamins C and E in nighttime serums.
Shi Y, Shen C, Zhang W, Efficacy and safety of a topical skincare regimen containing CE Ferulic serum and resveratrol BE serum following ablative fractional CO2 laser treatment, Journal of the European Academy of Dermatology and Venereology 2024;38 Suppl 6:18-25 — split-face RCT, resveratrol-containing serum reduced erythema and accelerated wound healing post-laser
Boo YC, Human Skin Lightening Efficacy of Resveratrol and Its Analogs: From in Vitro Studies to Cosmetic Applications, Antioxidants (Basel) 2019;8(9):332
Farris P, Zeichner J, Berson D, Efficacy and Tolerability of a Skin Brightening/Anti-Aging Cosmeceutical Containing Retinol 0.5%, Niacinamide, Hexylresorcinol, and Resveratrol, Journal of Drugs in Dermatology 2016;15(7):863-8
+−3 more ingredients
A multitasker that calms redness, evens out skin tone, and helps oily skin balance out. One of the safest do-a-little-of-everything ingredients.
Moro F et al., Skin Cancer Prevention and Antiaging: Role of Nicotinamide, International Journal of Molecular Sciences 2026
Passeron T et al., An Investigator-Blinded, Randomized Trial of a Broad-Spectrum Sunscreen Containing Sclareolide and Niacinamide, Dermatology and Therapy (Heidelberg) 2026
Vergilio MM et al., Topical Formulation with Niacinamide Combined with 5 MHz Ultrasound for Improving Skin Ageing, Current Medicinal Chemistry 2025
Pro-vitamin B5. Deeply hydrates and helps repair the skin barrier, calming dry or compromised skin.
Gao Y et al., Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment, Journal of Cosmetic Dermatology 2025;24(7):e70223 — double-blind RCT (n=60): panthenol mask decreased erythema, enhanced hydration, repaired barrier vs saline
Cho YS et al., Use of Dexpanthenol for Atopic Dermatitis-Benefits and Recommendations Based on Current Evidence, Journal of Clinical Medicine 2022;11(14):3943 — Korean-authored review; dexpanthenol improves barrier and reduces severity in mild-to-moderate AD
Heise R et al., Accelerated wound healing with a dexpanthenol-containing ointment after fractional ablative CO2 laser resurfacing of photo-damaged skin in a randomized prospective clinical trial, Cutaneous and Ocular Toxicology 2019;38(3):274-278 — RCT: dexpanthenol significantly faster wound closure vs petroleum jelly post-laser
Also called "cica," it calms redness, repairs the skin barrier, and speeds up healing. The go-to for irritated or reactive skin.
Hur N et al., A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women, Nutrients 2026
Borowicz KK et al., Geroprotective Potential of Centella asiatica: Modulation of Cellular Aging, Nutrients 2026
Su Z et al., The Effectiveness and Safety of a Skin Care Product With Centella asiatica Leaf Extract, Ceramide NP, and Panthenol in Subjects With Sensitive Skin: A Prospective, Observational Study, Journal of Cosmetic Dermatology 2025;24(7):e70324 — Sun Yat-Sen U 4-week study; cream provided rapid relief of facial redness and supported barrier function
Sources: PubMed · KCI · J-Stage · CNKI · Wanfang · SFD · MFDS · Cochrane · SCCS · CIR. Every entry points to a specific document. See methodology for what each outcome label means.
Layering conflicts
Ingredients in this product that can react with common actives. Avoid stacking unless noted.
- Vitamin Clow
Sensitive skin may flush.
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