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Shop LANEIGE Water Sleeping Mask Hydrating Korean Overnight Mask with Squalane & Probiotic-Derived Complex
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LANEIGE

Water Sleeping Mask Hydrating Korean Overnight Mask with Squalane & Probiotic-Derived Complex

~$15
DrynessAcneVisible poresDark spots

What it's good for

Key actives from our research database. Click any to read the full evidence dossier.

  • GlycerinModerate evidenceFull dossier ↗

    A workhorse hydrator that pulls water into your skin. In nearly every good moisturizer for a reason.

    Good for: Hydrating

  • SqualaneAnecdotal evidenceFull dossier ↗

    A lightweight oil that mimics what your skin already makes. Softens and seals in hydration without feeling greasy.

    Good for: Barrier repair, Hydrating

  • Lactobacillus FermentAnecdotal evidenceFull dossier ↗

    A "postbiotic" (dead probiotic bits) that talks to your skin microbiome without adding live bugs. Patches up a leaky barrier and is friendly even on very reactive skin.

    Good for: Barrier repair, Hydrating

  • NiacinamideStrong evidenceFull dossier ↗

    A multitasker that calms redness, evens out skin tone, and helps oily skin balance out. One of the safest do-a-little-of-everything ingredients.

    Good for: Brightening, Barrier repair, Anti-inflammatory

  • Hyaluronic AcidStrong evidenceFull dossier ↗

    A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.

    Good for: Hydrating

  • Beta-GlucanModerate evidenceFull dossier ↗

    A heavy-duty hydrator that also reduces irritation. Often called "better than hyaluronic acid" for sensitive skin.

    Good for: Hydrating, Anti-inflammatory

  • Snow MushroomAnecdotal evidenceFull dossier ↗

    Often pitched as the gentler cousin of hyaluronic acid. It holds water in the skin, fades less quickly in dry air, and quietly buffers against UV oxidative stress.

    Good for: Hydrating, Antioxidant, Barrier repair

  • Polyglutamic AcidAnecdotal evidenceFull dossier ↗

    A hydrator often pitched as "stronger than hyaluronic acid." It sits on the surface, locks water in, and helps your skin make more of its own moisturizers over time.

    Good for: Hydrating, Barrier repair

  • CeramidesStrong evidenceFull dossier ↗

    Refills the natural barrier between your skin cells. Locks moisture in, keeps irritants out, calms dry or damaged skin.

    Good for: Barrier repair

  • Vitamin EModerate evidenceFull dossier ↗

    A workhorse antioxidant that defends your skin from daily oxidative damage. Pairs especially well with vitamin C, and it's in nearly every good moisturizer for a reason.

    Good for: Antioxidant

Evidence behind the ingredients

Real citations from our research database, one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

GlycerinModerate evidence6 citations

A workhorse hydrator that pulls water into your skin. In nearly every good moisturizer for a reason.

Danby SG et al., Different types of emollient cream exhibit diverse physiological effects on the skin barrier in adults with atopic dermatitis, Clinical and Experimental Dermatology 2022;47(6):1154-1164 — glycerol+urea emollient delivered superior barrier-strengthening and irritant protection

2022Positive (efficacy)PMID:35167133View source ↗

Youssef R et al., Glycerol 85% efficacy on atopic skin and its microbiome: a randomized controlled trial, Journal of Dermatological Treatment 2021;32(7):730-736 — topical glycerol 85% RCT on atopic skin

2021Positive (efficacy)PMID:31869257View source ↗

Evans NJ et al., Human axillary skin condition is improved following incorporation of glycerol into the stratum corneum from an antiperspirant formulation, Archives of Dermatological Research 2017;309(9):739-748 — 4% glycerol penetrated axillary SC, reduced irritation, improved hydration

2017Positive (efficacy)PMID:28889318View source ↗
SqualaneAnecdotal evidence5 citations

A lightweight oil that mimics what your skin already makes. Softens and seals in hydration without feeling greasy.

Wolosik K et al., Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast, Molecules 2025;30(9):1964 — low-dose squalane (0.005-0.015%) restored collagen biosynthesis and wound healing in UVA-exposed human dermal fibroblasts

2025Mechanism onlyPMID:40363772View source ↗

Morgan AB et al., Explicating the multifunctional roles of tocotrienol and squalene in promoting skin health, Skin Health and Disease 2024;4(5):e448 — squalene/squalane promotes skin health via antioxidant, hydrating, emollient, anti-inflammatory mechanisms

2024Mechanism onlyPMID:39355739View source ↗

Fiume M et al., Safety Assessment of Squalane and Squalene as Used in Cosmetics, International Journal of Toxicology 2023;42(3_suppl):107S-109S — CIR expert-panel assessment concluding squalane is safe as a cosmetic ingredient

2023Safety assessmentPMID:37752766View source ↗
Lactobacillus FermentAnecdotal evidence6 citations

A "postbiotic" (dead probiotic bits) that talks to your skin microbiome without adding live bugs. Patches up a leaky barrier and is friendly even on very reactive skin.

Algieri F, Pimazzoni S et al. (Italy), Postbiotic derived from Lacticaseibacillus paracasei CNCM I-5220 as a novel approach to improve ageing-induced skin damage, Scientific Reports 2026 — 6-week topical postbiotic application reduced roughness and increased hydration, elasticity, and echogenicity vs placebo; boosted hyaluronic acid in keratinocytes and pro-collagen in fibroblasts

2026Positive (efficacy)PMID:42168426View source ↗

Flores Rodriguez JC et al. (Mexico/Colombia/Costa Rica), Postbiotics in Dermatology: A Literature Review of Emerging Topical Therapies for Acne, Rosacea, and Eczema, Cureus 2026;18(3) — review of 16 studies: postbiotics improved SCORAD and barrier function in atopic dermatitis; reduced inflammatory acne lesions 50-70% and suppressed sebum 42-72%

2026Meta-analysis (positive)PMID:42005241View source ↗

Flint E et al., Topical Probiotics Reduce Atopic Dermatitis Severity: A Systematic Review and Meta-Analysis, Cureus 2024;16(9):e70001 — SR/MA of topical Lactobacillus probiotics for atopic dermatitis

2024Meta-analysis (positive)PMID:39445279View source ↗
+7 more ingredients
NiacinamideStrong evidence10 citations

A multitasker that calms redness, evens out skin tone, and helps oily skin balance out. One of the safest do-a-little-of-everything ingredients.

Moro F et al., Skin Cancer Prevention and Antiaging: Role of Nicotinamide, International Journal of Molecular Sciences 2026

2026Mechanism onlyPMID:42278444View source ↗

Passeron T et al., An Investigator-Blinded, Randomized Trial of a Broad-Spectrum Sunscreen Containing Sclareolide and Niacinamide, Dermatology and Therapy (Heidelberg) 2026

2026Positive (efficacy)PMID:41240206View source ↗

Vergilio MM et al., Topical Formulation with Niacinamide Combined with 5 MHz Ultrasound for Improving Skin Ageing, Current Medicinal Chemistry 2025

2025Positive (efficacy)PMID:39171587View source ↗
Hyaluronic AcidStrong evidence7 citations

A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.

Karabat MU, Tuncer MC. Effects of hyaluronic acid on skin at the cellular level: a systematic review. Rev Assoc Med Bras. 2025;71(8):e20250208. — Systematic review of 45 studies found low-molecular-weight HA stimulates keratinocyte proliferation and migration while high-molecular-weight HA drives skin hydration, supporting topical HA as an effective skin-hydrating and barrier-supporting ingredient.

2025Meta-analysis (positive)PMID:40990743View source ↗

Bravo B et al., Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence, Dermatology and Therapy 2022;12(12):2657-2680 — HA-based cosmeceuticals reliably improve hydration and signs of skin aging

2022Meta-analysis (positive)PMID:36200921View source ↗

Lee SG et al., Hyaluronan Oligosaccharides Improve Rosacea-Like Phenotype through Anti-Inflammatory and Epidermal Barrier-Improving Effects, Annals of Dermatology 2020

2020Mechanism onlyPMID:33911737View source ↗
Beta-GlucanModerate evidence5 citations

A heavy-duty hydrator that also reduces irritation. Often called "better than hyaluronic acid" for sensitive skin.

Feng X et al., Exploring the Properties and Application Potential of beta-Glucan in Skin Care, Food Science and Nutrition 2025;13(4):e70212 — review concludes beta-glucan exhibits antioxidant, anti-inflammatory, barrier repair, and moisturizing bioactivities

2025Mechanism onlyPMID:40291929View source ↗

Kussie HC et al., Avenanthramide and beta-Glucan Therapeutics Accelerate Wound Healing Via Distinct and Nonoverlapping Mechanisms, Advances in Wound Care 2024;13(4):155-166 — in vivo: beta-glucan accelerated wound closure with increased angiogenesis

2024Positive (efficacy)PMID:38299969View source ↗

Cao Y et al., Improving the outcome of treating striae gravidarum by combined therapies using topical β-glucan and 1565-nm non-ablative fractional laser, Journal of Dermatology 2022;49(9):829-836 — RCT; topical beta-glucan twice daily for 12 weeks on stretch marks

2022Positive (efficacy)PMID:35570397View source ↗
Snow MushroomAnecdotal evidence4 citations

Often pitched as the gentler cousin of hyaluronic acid. It holds water in the skin, fades less quickly in dry air, and quietly buffers against UV oxidative stress.

Zhang Y et al., iTRAQ-Based Proteomic Profiling of Skin Aging Protective Effects of Tremella fuciformis-Derived Polysaccharides on D-Galactose-Induced Aging Mice, Molecules 2024

2024Mechanism onlyPMID:39519833View source ↗

Lin M et al., Tremella fuciformis polysaccharides alleviates UV-provoked skin cell damage via regulation of thioredoxin interacting protein and thioredoxin reductase 2, Photochemistry and Photobiology Sciences 2023;22(10) — topical TFPS treatment in chronic UV-irradiated mouse model reduced photoaging markers and protected skin cells from UVA-induced damage

2023Positive (efficacy)PMID:37458972View source ↗

Shen T et al., Tremella fuciformis polysaccharides inhibit UVA-induced photodamage of human dermal fibroblast cells by up-regulating Nrf2/Keap1 pathways, Journal of Cosmetic Dermatology 2021

2021Mechanism onlyPMID:33686752View source ↗
Polyglutamic AcidAnecdotal evidence3 citations

A hydrator often pitched as "stronger than hyaluronic acid." It sits on the surface, locks water in, and helps your skin make more of its own moisturizers over time.

Ko HJ et al., Poly-gamma-Glutamic Acid from a Novel Bacillus subtilis Strain: Strengthening the Skin Barrier and Improving Moisture Retention in Keratinocytes and a Reconstructed Skin Model, International Journal of Molecular Sciences 2025

2025Mechanism onlyPMID:39940752View source ↗

Li C, Ma H, Li P, Zhang S et al., Cucumber (Cucumis sativus L.) with heterologous poly-gamma-glutamic acid has skin moisturizing, whitening and anti-wrinkle effects, International Journal of Biological Macromolecules 2024;263(Pt 1):130229 — transgenic gamma-PGA-producing cucumber outperformed standard gamma-PGA and hyaluronic acid on hydration, wrinkles (-19 to -25%), and melanin reduction in human skin testing

2024Positive (efficacy)PMID:38336313View source ↗

Yang R et al., Injectable adaptive self-healing hyaluronic acid/poly(gamma-glutamic acid) hydrogel for cutaneous wound healing, Acta Biomaterialia 2021;127:102-115 — HA/gamma-PGA self-healing hydrogel significantly accelerated full-thickness wound closure with enhanced angiogenesis and collagen deposition vs Tegaderm

2021Mechanism onlyPMID:33813093View source ↗
CeramidesStrong evidence7 citations

Refills the natural barrier between your skin cells. Locks moisture in, keeps irritants out, calms dry or damaged skin.

Andrew PV et al., Topical supplementation with physiological lipids rebalances the stratum corneum ceramide profile and strengthens skin barrier function in adults predisposed to atopic dermatitis, British Journal of Dermatology 2025;193(4):729-740 — physiological-lipid emulsion raised SC ceramide NP/AP and improved barrier function vs control

2025Positive (efficacy)PMID:40408261View source ↗

Nugroho WT, Sawitri, Astindari, Utomo B, Listiawan MY, Ervianti E, Astari L. The Efficacy of Moisturisers Containing Ceramide Compared with Other Moisturisers in the Management of Atopic Dermatitis: A Systematic Literature Review and Meta-Analysis. Indian J Dermatol. 2023;68(1):53-58. — Meta-analysis of 5 studies found ceramide-containing moisturisers produced significantly greater improvement in SCORAD compared with non-ceramide moisturisers in atopic dermatitis.

2023Meta-analysis (positive)PMID:37151263View source ↗

Shindo S et al., Effects of a moisturizer containing pseudo-ceramide and a eucalyptus extract on sweating function in adult atopic dermatitis: a double-blind, randomized, controlled left-right comparison clinical trial, Journal of Cosmetic Dermatology 2022;21(10):4503-4509 — pseudo-ceramide + eucalyptus moisturizer restored sweating function and barrier in AD adults

2022Positive (efficacy)PMID:35298858View source ↗
Vitamin EModerate evidence6 citations

A workhorse antioxidant that defends your skin from daily oxidative damage. Pairs especially well with vitamin C, and it's in nearly every good moisturizer for a reason.

Neves JR et al., Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs, Journal of Cosmetic Dermatology 2022;21(10):4462-4469 — tocopherol-containing antioxidant serum reduced pollution-induced damage and improved aging signs

2022Positive (efficacy)PMID:35150043View source ↗

Warshaw EM et al., Patch Testing With Tocopherol and Tocopherol Acetate: The North American Contact Dermatitis Group Experience, 2001 to 2016, Dermatitis 2021;32(5):308-318 — 15-year NACDG data: positive patch-test reactions to tocopherol rare given widespread cosmetic use

2021Safety assessmentPMID:34238818View source ↗

Lin FH et al., Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin, Journal of Investigative Dermatology 2005;125(4):826-832 — ferulic acid + vit C + vit E combo doubled photoprotection vs C+E alone (cross-listed; same paper cited for Ferulic Acid and Vit C)

2005Positive (efficacy)PMID:16185284View source ↗

Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.

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