Best skincare for acne
Breakouts come from a mix of clogged pores, excess oil, bacteria, and inflammation, so the ingredients that help work in different ways. Here are the actives we track that target acne, ranked by how much published evidence backs them, plus the products in our catalog that feature them.
Ingredients that help
Ranked by evidence tier, then by how many studies we cite. Tap any ingredient for the full breakdown and its sources.
- NiNiacinamideStrong · 10 studies (sample)
A multitasker that calms redness, evens out skin tone, and helps oily skin balance out. One of the safest do-a-little-of-everything ingredients.
- SaSalicylic AcidStrong · 9 studies (sample)
Goes into your pores and dissolves the oil and dead skin clogging them. Best for blackheads, whiteheads, and oily, acne-prone skin.
- AzAzelaic AcidStrong · 9 studies (sample)
Calms redness, fades acne marks, and clears bumps, all without aggravating sensitive skin. Pregnancy-safe.
- BpBenzoyl PeroxideStrong · 7 studies (sample)
Kills the bacteria that cause inflammatory acne. The first thing to reach for when you have red, painful pimples.
- AdAdapaleneStrong · 6 studies (sample)
A gentler prescription retinoid that focuses on clogged pores and acne. Better tolerated than tretinoin for most skin.
- ZpZinc PyrithioneStrong · 6 studies (sample)
The active in classic anti-dandruff and anti-Malassezia formulas. It is an FDA-approved OTC antidandruff active, and RCTs show it reduces flaking and the look of dandruff about as well as leading medicated washes. The reason your medicated body wash actually works.
- TrTretinoinStrong · 5 studies (sample)
The prescription-strength version of retinol. Same goals (smoother, more even skin), but works faster and is more irritating. Needs a doctor.
- HeHeartleafModerate · 8 studies
A calming K-beauty botanical that's also antibacterial, so it pairs well for acne-prone, sensitive skin.
- PrPropolisModerate · 6 studies
A bee-made resin that's antibacterial and anti-inflammatory. Calms breakouts and hydrates at the same time.
- TtTea Tree OilModerate · 6 studies
A natural acne spot-treatment that kills the bacteria behind red, painful pimples. Slower than benzoyl peroxide but with fewer side effects when used at 5%.
- HxHypochlorous AcidModerate · 6 studies
A "molecule your own immune cells make," now bottled. Kills surface bacteria without nuking the barrier, soothes the feeling of itch and redness on reactive skin, and gives compromised or post-procedure skin a clean reset, gentle enough to spray around eyes.
- HoHoneyModerate · 5 studies
An ancient humectant and antimicrobial ingredient with a long research track record. Its sugar matrix and flavonoids help draw in moisture and support skin comfort; formulas pairing honey with beeswax and olive oil have shown improvement in dry, irritation-prone skin in controlled trials.
Top picks for acne
Catalog picks that feature these actives, scored by the same engine the routine builder uses. Prices are approximate; check retailer for current pricing.
Salicylic Acid goes into your pores and dissolves the oil and dead skin clogging them, with strong evidence for acne.
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Adapalene a gentler prescription retinoid that focuses on clogged pores and acne, with strong evidence for acne.
Affiliate links: we may earn a small commission at no extra cost to you. Full disclosure.
Salicylic Acid goes into your pores and dissolves the oil and dead skin clogging them, with strong evidence for acne.
Affiliate links: we may earn a small commission at no extra cost to you. Full disclosure.
Niacinamide a multitasker that calms redness, evens out skin tone, and helps oily skin balance out, with strong evidence for acne.
Affiliate links: we may earn a small commission at no extra cost to you. Full disclosure.
Benzoyl Peroxide kills the bacteria that cause inflammatory acne, with strong evidence for acne.
Affiliate links: we may earn a small commission at no extra cost to you. Full disclosure.
Salicylic Acid goes into your pores and dissolves the oil and dead skin clogging them, with strong evidence for acne.
Affiliate links: we may earn a small commission at no extra cost to you. Full disclosure.
Still deciding?
Head-to-head comparisons for the ingredients above.