For your skin
A "molecule your own immune cells make," now bottled. Kills surface bacteria without nuking the barrier, soothes the feeling of itch and redness on reactive skin, and gives compromised or post-procedure skin a clean reset, gentle enough to spray around eyes.
Want the science? Keep reading ↓Mechanism of action
Endogenous oxidant produced by neutrophil myeloperoxidase; at cosmetic concentrations (~0.01-0.05%) it is broadly antimicrobial yet non-cytotoxic, inhibits NF-κB-driven inflammatory genes (Ptgs2, Il19, Tlr4), and blunts itch signaling in atopic models.
Why we tier this moderate
6 cited papers across 3 countries. The mechanism is well-described and there's at least one controlled trial in the literature, but we tier this Moderate rather than Strong to stay honest about how many specific papers we cite directly.
Cited research
Haralovic V, Mokos M, Spoljar S, et al. Hypochlorous Acid: Clinical Insights and Experience in Dermatology, Surgery, Dentistry, Ophthalmology, Rhinology, and Other Specialties. Biomedicines. 2025 Nov 28;13(12):2921. — Narrative review synthesizing 61 clinical studies on HOCl across dermatological indications including acne, wound care, and atopic dermatitis.
Burian EA et al., Effect of Stabilized Hypochlorous Acid on Re-epithelialization and Bacterial Bioburden in Acute Wounds: A Randomized Controlled Trial in Healthy Volunteers, Acta Derm Venereol 2022;102():adv00727 — controlled: stabilized HOCl aided re-epithelialization
Wentworth AB et al., Topical hypochlorous acid (HOCl) blocks inflammatory gene expression and tumorigenic progression in UV-exposed SKH-1 high risk mouse skin, Redox Biology 2021;46:102108 — topical HOCl suppressed UV-induced inflammatory genes (Ptgs2, Il19, Tlr4) and tumor burden in photocarcinogenesis model
Dorostkar A et al., Sodium Hypochlorite 0.005% Versus Placebo in the Treatment of Mild to Moderate Acne: A Double-Blind Randomized Controlled Trial, Dermatol Pract Concept 2021;11(3):e2021046 — RCT 0.005% NaOCl vs placebo
Gold MH, Andriessen A, Bhatia AC, et al. Topical stabilized hypochlorous acid: The future gold standard for wound care and scar management in dermatologic and plastic surgery procedures. Journal of Cosmetic Dermatology. 2020 Feb;19(2):308-313. — Clinical review supporting stabilized HOCl as wound care and scar management standard with strong tolerability and antimicrobial evidence.
Fukuyama T et al., Hypochlorous acid is antipruritic and anti-inflammatory in a mouse model of atopic dermatitis, Clinical and Experimental Allergy 2018;48(1):78-88 — 0.05% HOCl hydrogel significantly reduced scratching, inflammatory cytokines, and itch behavior in AD model, comparably to topical steroid
Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.