Probio Cica Intensive Ampoule with Ceramide 50ml
What it's good for
Key actives from our research database. Click any to read the full evidence dossier.
Another cica (centella) compound. This one specifically pushes collagen production, so the benefit is more about firmness than calming.
Good for: Anti-aging, Anti-inflammatory
A hydrator often pitched as "stronger than hyaluronic acid." It sits on the surface, locks water in, and helps your skin make more of its own moisturizers over time.
Good for: Hydrating, Barrier repair
Also called "cica," it calms redness, repairs the skin barrier, and speeds up recovery. The go-to for irritated or reactive skin.
Good for: Anti-inflammatory, Barrier repair
A multitasker that calms redness, evens out skin tone, and helps oily skin balance out. One of the safest do-a-little-of-everything ingredients.
Good for: Brightening, Barrier repair, Anti-inflammatory
A gentle smoother and skin-soother. Reduces flakiness and helps the surface look more even.
Good for: Anti-inflammatory, Hydrating
Pro-vitamin B5. Deeply hydrates and helps repair the skin barrier, calming dry or compromised skin.
Good for: Hydrating, Barrier repair
Evidence behind the ingredients
Real citations from our research database, one per tracked active in this product. Click any ingredient name to read its full evidence dossier.
Another cica (centella) compound. This one specifically pushes collagen production, so the benefit is more about firmness than calming.
Bandopadhyay S et al., Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review, Journal of Cellular and Molecular Medicine 2023;27(5):593-608 — asiaticoside and madecassoside have wound healing, anti-inflammatory, and dermatological potential
Park KS, Pharmacological Effects of Centella asiatica on Skin Diseases: Evidence and Possible Mechanisms, Evidence-Based Complementary and Alternative Medicine 2021;2021:5462633 — documents asiaticoside efficacy across wound healing, scarring and inflammatory dermatoses
Peng Q et al., Transdermal characteristics and mechanism of asiaticoside nanoemulsions and asiaticoside nanoemulsions-based gels, Zhongguo Zhong Yao Za Zhi (China Journal of Chinese Materia Medica) 2018;43(9):1857-1863 — asiaticoside nanoemulsions achieved 6-7x greater drug permeation and 5-6x greater skin deposition vs commercial cream
A hydrator often pitched as "stronger than hyaluronic acid." It sits on the surface, locks water in, and helps your skin make more of its own moisturizers over time.
Ko HJ et al., Poly-gamma-Glutamic Acid from a Novel Bacillus subtilis Strain: Strengthening the Skin Barrier and Improving Moisture Retention in Keratinocytes and a Reconstructed Skin Model, International Journal of Molecular Sciences 2025
Li C, Ma H, Li P, Zhang S et al., Cucumber (Cucumis sativus L.) with heterologous poly-gamma-glutamic acid has skin moisturizing, whitening and anti-wrinkle effects, International Journal of Biological Macromolecules 2024;263(Pt 1):130229 — transgenic gamma-PGA-producing cucumber outperformed standard gamma-PGA and hyaluronic acid on hydration, wrinkles (-19 to -25%), and melanin reduction in human skin testing
Yang R et al., Injectable adaptive self-healing hyaluronic acid/poly(gamma-glutamic acid) hydrogel for cutaneous wound healing, Acta Biomaterialia 2021;127:102-115 — HA/gamma-PGA self-healing hydrogel significantly accelerated full-thickness wound closure with enhanced angiogenesis and collagen deposition vs Tegaderm
Also called "cica," it calms redness, repairs the skin barrier, and speeds up recovery. The go-to for irritated or reactive skin.
Hur N et al., A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women, Nutrients 2026
Borowicz KK et al., Geroprotective Potential of Centella asiatica: Modulation of Cellular Aging, Nutrients 2026
Witkowska K et al., Topical Application of Centella asiatica in Wound Healing: Recent Insights into Mechanisms and Clinical Efficacy, Pharmaceutics 2024;16(10):1252 — modern hydrogel and nanostructured Centella delivery systems accelerate wound healing across wound types
+−3 more ingredients
A multitasker that calms redness, evens out skin tone, and helps oily skin balance out. One of the safest do-a-little-of-everything ingredients.
Moro F et al., Skin Cancer Prevention and Antiaging: Role of Nicotinamide, International Journal of Molecular Sciences 2026
Passeron T et al., An Investigator-Blinded, Randomized Trial of a Broad-Spectrum Sunscreen Containing Sclareolide and Niacinamide, Dermatology and Therapy (Heidelberg) 2026
Vergilio MM et al., Topical Formulation with Niacinamide Combined with 5 MHz Ultrasound for Improving Skin Ageing, Current Medicinal Chemistry 2025
A gentle smoother and skin-soother. Reduces flakiness and helps the surface look more even.
Xu Z et al., Efficacy and Safety of Topical Compound Heparin Sodium Allantoin Gel for the Treatment of Rosacea, Journal of Cosmetic Dermatology 2025;24(4):e70129 — RCT (n=82, 12 weeks): allantoin gel improved erythema and alleviated itching/burning vs traditional therapy
Tan C et al., The combination of allantoin, bisabolol, D-panthenol and dipotassium glycyrrhizinate mitigates UVB-induced PGE2 synthesis by keratinocytes, International Journal of Cosmetic Science 2024;46(5):691-701 — in vitro: allantoin combination reduced UVB-induced PGE2, IL-1α, IL-6, IL-8, TNFα
Saucedo-Acuna RA et al. (Mexico), Characterization and In Vivo Assay of Allantoin-Enriched Pectin Hydrogel for the Treatment of Skin Wounds, International Journal of Molecular Sciences 2023;24(8):7377 — allantoin-pectin hydrogel reduced wound healing time by ~71% with complete closure at day 15 in rat model
Pro-vitamin B5. Deeply hydrates and helps repair the skin barrier, calming dry or compromised skin.
Gao Y et al., Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment, Journal of Cosmetic Dermatology 2025;24(7):e70223 — double-blind RCT (n=60): panthenol mask decreased erythema, enhanced hydration, repaired barrier vs saline
Cho YS et al., Use of Dexpanthenol for Atopic Dermatitis-Benefits and Recommendations Based on Current Evidence, Journal of Clinical Medicine 2022;11(14):3943 — Korean-authored review; dexpanthenol improves barrier and reduces severity in mild-to-moderate AD
Heise R et al., Accelerated wound healing with a dexpanthenol-containing ointment after fractional ablative CO2 laser resurfacing of photo-damaged skin in a randomized prospective clinical trial, Cutaneous and Ocular Toxicology 2019;38(3):274-278 — RCT: dexpanthenol significantly faster wound closure vs petroleum jelly post-laser
Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.
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