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Shop Isntree Hyaluronic Acid Toner Plus 200ml
Toner
Isntree

Hyaluronic Acid Toner Plus 200ml

~$19· 200ml
RednessDryness

What it's good for

Key actives from our research database. Click any to read the full evidence dossier.

  • Hyaluronic AcidStrong evidenceFull dossier ↗

    A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.

    Good for: Hydrating

  • Beta-GlucanModerate evidenceFull dossier ↗

    A heavy-duty hydrator that also reduces irritation. Often called "better than hyaluronic acid" for sensitive skin.

    Good for: Hydrating, Anti-inflammatory

  • PanthenolModerate evidenceFull dossier ↗

    Pro-vitamin B5. Deeply hydrates and helps repair the skin barrier, calming dry or compromised skin.

    Good for: Hydrating, Barrier repair

  • Sodium PCAAnecdotal evidenceFull dossier ↗

    Replenishes one of the actual humectant molecules your own skin makes. Levels drop in eczema and with age, so topping it up genuinely helps dry, dehydrated, or atopic-prone skin feel less tight.

    Good for: Hydrating, Barrier repair

  • Aloe VeraModerate evidenceFull dossier ↗

    Calms irritation and adds light hydration. The classic for sunburned or reactive skin.

    Good for: Anti-inflammatory, Hydrating

Evidence behind the ingredients

Real citations from our research database, one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

Hyaluronic AcidStrong evidence7 citations

A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.

Karabat MU, Tuncer MC. Effects of hyaluronic acid on skin at the cellular level: a systematic review. Rev Assoc Med Bras. 2025;71(8):e20250208. — Systematic review of 45 studies found low-molecular-weight HA stimulates keratinocyte proliferation and migration while high-molecular-weight HA drives skin hydration, supporting topical HA as an effective skin-hydrating and barrier-supporting ingredient.

2025Meta-analysis (positive)PMID:40990743View source ↗

Bravo B et al., Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence, Dermatology and Therapy 2022;12(12):2657-2680 — HA-based cosmeceuticals reliably improve hydration and signs of skin aging

2022Meta-analysis (positive)PMID:36200921View source ↗

Lee SG et al., Hyaluronan Oligosaccharides Improve Rosacea-Like Phenotype through Anti-Inflammatory and Epidermal Barrier-Improving Effects, Annals of Dermatology 2020

2020Mechanism onlyPMID:33911737View source ↗
Beta-GlucanModerate evidence5 citations

A heavy-duty hydrator that also reduces irritation. Often called "better than hyaluronic acid" for sensitive skin.

Feng X et al., Exploring the Properties and Application Potential of beta-Glucan in Skin Care, Food Science and Nutrition 2025;13(4):e70212 — review concludes beta-glucan exhibits antioxidant, anti-inflammatory, barrier repair, and moisturizing bioactivities

2025Mechanism onlyPMID:40291929View source ↗

Kussie HC et al., Avenanthramide and beta-Glucan Therapeutics Accelerate Wound Healing Via Distinct and Nonoverlapping Mechanisms, Advances in Wound Care 2024;13(4):155-166 — in vivo: beta-glucan accelerated wound closure with increased angiogenesis

2024Positive (efficacy)PMID:38299969View source ↗

Cao Y et al., Improving the outcome of treating striae gravidarum by combined therapies using topical β-glucan and 1565-nm non-ablative fractional laser, Journal of Dermatology 2022;49(9):829-836 — RCT; topical beta-glucan twice daily for 12 weeks on stretch marks

2022Positive (efficacy)PMID:35570397View source ↗
PanthenolModerate evidence5 citations

Pro-vitamin B5. Deeply hydrates and helps repair the skin barrier, calming dry or compromised skin.

Gao Y et al., Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment, Journal of Cosmetic Dermatology 2025;24(7):e70223 — double-blind RCT (n=60): panthenol mask decreased erythema, enhanced hydration, repaired barrier vs saline

2025Positive (efficacy)PMID:40613435View source ↗

Cho YS et al., Use of Dexpanthenol for Atopic Dermatitis-Benefits and Recommendations Based on Current Evidence, Journal of Clinical Medicine 2022;11(14):3943 — Korean-authored review; dexpanthenol improves barrier and reduces severity in mild-to-moderate AD

2022Meta-analysis (positive)PMID:35887707View source ↗

Heise R et al., Accelerated wound healing with a dexpanthenol-containing ointment after fractional ablative CO2 laser resurfacing of photo-damaged skin in a randomized prospective clinical trial, Cutaneous and Ocular Toxicology 2019;38(3):274-278 — RCT: dexpanthenol significantly faster wound closure vs petroleum jelly post-laser

2019Positive (efficacy)PMID:30897983View source ↗
+2 more ingredients
Sodium PCAAnecdotal evidence4 citations

Replenishes one of the actual humectant molecules your own skin makes. Levels drop in eczema and with age, so topping it up genuinely helps dry, dehydrated, or atopic-prone skin feel less tight.

Novel design of pyrrolidonecarboxylic acid and sodium dilauramidoglutamide lysine complex for targeted drug delivery to human stratum corneum, International Journal of Pharmaceutics 2025

2025Mechanism onlyPMID:40187708View source ↗

Baldwin H, Del Rosso J, Going Beyond Ceramides in Moisturizers: The Role of Natural Moisturizing Factors, Journal of Drugs in Dermatology 2024 — review establishing PCA (pyrrolidone carboxylic acid) as a core skin natural moisturizing factor alongside amino acids, urea, lactate, and electrolytes; essential to barrier function and xerosis treatment

2024Mechanism onlyPMID:38834224View source ↗

Li L et al., Association Between Skin Acid Mantle, Natural Moisturizing Factors, and Antibacterial Activity Against S. aureus in the Stratum Corneum, Clinical Cosmetic and Investigational Dermatology 2023 — PCA and urocanic acid as NMF components contribute to skin antibacterial defense; 1-unit pH drop = 68.1% S. aureus cell death

2023Mechanism onlyPMID:37378303View source ↗
Aloe VeraModerate evidence7 citations

Calms irritation and adds light hydration. The classic for sunburned or reactive skin.

Huang YN et al., Effects of Aloe vera on Burn Injuries: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Journal of Burn Care & Research 2024;45(6):1536-1545 — topical aloe vera reduced burn wound-healing time

2024Meta-analysis (positive)PMID:38605441View source ↗

Tungkasamit T et al., Reduction in severity of radiation-induced dermatitis in head and neck cancer patients treated with topical aloe vera gel: A randomized multicenter double-blind placebo-controlled trial, European Journal of Oncology Nursing 2022;59:102164 — aloe vera reduced severity of moderate-to-severe radiation dermatitis

2022Positive (efficacy)PMID:35767935View source ↗

Sharma S et al., Second-Degree Burns and Aloe Vera: A Meta-analysis and Systematic Review, Advances in Skin & Wound Care 2022;35(11):1-9 — topical aloe vera shortened time to healing for second-degree burns

2022Meta-analysis (positive)PMID:36264753View source ↗

Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.

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