Ingredients Anti-inflammatory Aloe Vera
47Av
Sourced from herb
Tier · Moderate evidence
Anti-inflammatory · Hydrating

Aloe Vera

INCI: Aloe Barbadensis Leaf Juice · Also called: Aloe

Calms irritation and adds light hydration. The classic for sunburned or reactive skin.

For your skin

Calms irritation and adds light hydration. The classic for sunburned or reactive skin.

Want the science? Keep reading ↓

Mechanism of action

Polysaccharide- and glycoprotein-rich plant gel that soothes irritation and supports wound healing.

Why we tier this moderate

5 cited papers across 3 countries. The mechanism is well-described and there's at least one controlled trial in the literature, but we tier this Moderate rather than Strong to stay honest about how many specific papers we cite directly.

3
International
1
Korea
1
United States

Layering matrix

Cited research

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Tungkasamit T et al., Reduction in severity of radiation-induced dermatitis in head and neck cancer patients treated with topical aloe vera gel: A randomized multicenter double-blind placebo-controlled trial, European Journal of Oncology Nursing 2022;59:102164 — aloe vera reduced severity of moderate-to-severe radiation dermatitis

2022Positive — efficacyPMID:35767935View source ↗
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Hekmatpou D et al., The effect of aloe vera clinical trials on prevention and healing of skin wound: a systematic review, Iranian Journal of Medical Sciences 2019;44(1):1-9

2019Meta-analysis — positivePMID:30666070View source ↗
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Burusapat C et al., Topical Aloe Vera Gel for Accelerated Wound Healing of Split-Thickness Skin Graft Donor Sites: A Double-Blind, Randomized, Controlled Trial and Systematic Review, Plastic and Reconstructive Surgery 2018;142(1):217-226 — aloe vera gel shortened donor-site reepithelialization to 11.5 vs 13.7 days

2018Positive — efficacyPMID:29649056View source ↗
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Cho S et al., Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and Increases Type I Procollagen Gene Expression in Human Skin in vivo, Annals of Dermatology 2009;21(1):6-11 — dietary aloe gel significantly improved wrinkles and elasticity in photoaged human skin with increased collagen production

2009Positive — efficacyPMID:20548848View source ↗
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Surjushe A et al., Aloe vera: a short review, Indian Journal of Dermatology 2008;53(4):163-6 — concluded "controlled trials are needed to determine real efficacy"

2008InconclusivePMID:19882025View source ↗

Sources: PubMed · KCI · J-Stage · CNKI · Wanfang · SFD · MFDS · Cochrane · SCCS · CIR. Every entry points to a specific document. See methodology for what each outcome label means.