PDRN Capsule Cream 100
What it's good for
Key actives from our research database. Click any to read the full evidence dossier.
A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.
Good for: Hydrating
Pro-vitamin B5. Deeply hydrates and helps repair the skin barrier, calming dry or compromised skin.
Good for: Hydrating, Barrier repair
The "salmon DNA" trending in K-beauty and Korean clinics. Strong wound-healing pedigree translated into anti-aging. Speeds repair after lasers/microneedling, smooths fine lines, and brightens. Often layered with vitamin C and niacinamide. Worth knowing: salmon- or trout-derived PDRN has much stronger clinical evidence than plant ("phyto") PDRN, and the dose matters more than the marketing. Favor products that list a real PDRN concentration (roughly 1,000+ ppm) over big headline numbers on plant-derived versions.
Good for: Barrier repair, Anti-aging
Refills the natural barrier between your skin cells. Locks moisture in, keeps irritants out, calms dry or damaged skin.
Good for: Barrier repair
Evidence behind the ingredients
Real citations from our research database, one per tracked active in this product. Click any ingredient name to read its full evidence dossier.
A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.
Karabat MU, Tuncer MC. Effects of hyaluronic acid on skin at the cellular level: a systematic review. Rev Assoc Med Bras. 2025;71(8):e20250208. — Systematic review of 45 studies found low-molecular-weight HA stimulates keratinocyte proliferation and migration while high-molecular-weight HA drives skin hydration, supporting topical HA as an effective skin-hydrating and barrier-supporting ingredient.
Bravo B et al., Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence, Dermatology and Therapy 2022;12(12):2657-2680 — HA-based cosmeceuticals reliably improve hydration and signs of skin aging
Lee SG et al., Hyaluronan Oligosaccharides Improve Rosacea-Like Phenotype through Anti-Inflammatory and Epidermal Barrier-Improving Effects, Annals of Dermatology 2020
Pro-vitamin B5. Deeply hydrates and helps repair the skin barrier, calming dry or compromised skin.
Gao Y et al., Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment, Journal of Cosmetic Dermatology 2025;24(7):e70223 — double-blind RCT (n=60): panthenol mask decreased erythema, enhanced hydration, repaired barrier vs saline
Cho YS et al., Use of Dexpanthenol for Atopic Dermatitis-Benefits and Recommendations Based on Current Evidence, Journal of Clinical Medicine 2022;11(14):3943 — Korean-authored review; dexpanthenol improves barrier and reduces severity in mild-to-moderate AD
Heise R et al., Accelerated wound healing with a dexpanthenol-containing ointment after fractional ablative CO2 laser resurfacing of photo-damaged skin in a randomized prospective clinical trial, Cutaneous and Ocular Toxicology 2019;38(3):274-278 — RCT: dexpanthenol significantly faster wound closure vs petroleum jelly post-laser
The "salmon DNA" trending in K-beauty and Korean clinics. Strong wound-healing pedigree translated into anti-aging. Speeds repair after lasers/microneedling, smooths fine lines, and brightens. Often layered with vitamin C and niacinamide. Worth knowing: salmon- or trout-derived PDRN has much stronger clinical evidence than plant ("phyto") PDRN, and the dose matters more than the marketing. Favor products that list a real PDRN concentration (roughly 1,000+ ppm) over big headline numbers on plant-derived versions.
Lee D et al., Skin Regeneration and Barrier-Improvement Efficacy of Polydeoxyribonucleotide Isolated from Panax Ginseng Adventitious Root, Molecules 2023;28(21):7240 — plant-derived PDRN promoted keratinocyte/fibroblast proliferation and strengthened barrier function
Lee S, Won KH et al., A Mixture of Topical Forms of Polydeoxyribonucleotide, Vitamin C, and Niacinamide Attenuated Skin Pigmentation and Increased Skin Elasticity by Modulating Nrf2, Molecules 2022;27(4):1276 — topical PDRN + Vit C + niacinamide reduced melanin and improved elasticity in UV-B model, comparable to hydroquinone
Squadrito F et al., Polydeoxyribonucleotide: A Promising Biological Platform to Accelerate Impaired Skin Wound Healing, Pharmaceuticals (Basel) 2021;14(11):1103 — review documenting PDRN activation of adenosine A2A receptors, VEGF release, and accelerated wound healing across diabetic, thermal, and ischemic models
+−1 more ingredient
Refills the natural barrier between your skin cells. Locks moisture in, keeps irritants out, calms dry or damaged skin.
Andrew PV et al., Topical supplementation with physiological lipids rebalances the stratum corneum ceramide profile and strengthens skin barrier function in adults predisposed to atopic dermatitis, British Journal of Dermatology 2025;193(4):729-740 — physiological-lipid emulsion raised SC ceramide NP/AP and improved barrier function vs control
Nugroho WT, Sawitri, Astindari, Utomo B, Listiawan MY, Ervianti E, Astari L. The Efficacy of Moisturisers Containing Ceramide Compared with Other Moisturisers in the Management of Atopic Dermatitis: A Systematic Literature Review and Meta-Analysis. Indian J Dermatol. 2023;68(1):53-58. — Meta-analysis of 5 studies found ceramide-containing moisturisers produced significantly greater improvement in SCORAD compared with non-ceramide moisturisers in atopic dermatitis.
Shindo S et al., Effects of a moisturizer containing pseudo-ceramide and a eucalyptus extract on sweating function in adult atopic dermatitis: a double-blind, randomized, controlled left-right comparison clinical trial, Journal of Cosmetic Dermatology 2022;21(10):4503-4509 — pseudo-ceramide + eucalyptus moisturizer restored sweating function and barrier in AD adults
Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.
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