Shop SKIN1004 Tone Balancing Capsule Ampoule Niacinamide + TXA 100ml
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SKIN1004

Tone Balancing Capsule Ampoule Niacinamide + TXA 100ml

~$20· 100ml
AcneDark spotsRadianceRedness

Evidence behind the ingredients

Real citations from our research database — one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

Tranexamic AcidStrong evidence8 citations

Fades stubborn dark patches like melasma and deep marks left behind by acne or hormonal shifts. The one to reach for when other brighteners haven't worked.

Liang Y et al., Comparative efficacy and safety of tranexamic acid for melasma by different administration methods: A systematic review and network meta-analysis, Journal of Cosmetic Dermatology 2024 — oral TXA + topical agents most effective delivery route

2024Meta-analysis — positivePMID:38059683View source ↗

Tranexamic Acid Ameliorates Skin Hyperpigmentation by Downregulating Endothelin-1 Expression in Dermal Microvascular Endothelial Cells, Annals of Dermatology 2024;36(3):151-162 — mechanism study showing oral TXA suppresses endothelin-1 in vascular endothelial cells

2024Mechanism onlyPMID:38816976View source ↗

Calacattawi R, Alshahrani M, Aleid M et al., Tranexamic acid as a therapeutic option for melasma management: a meta-analysis and systematic review of randomized controlled trials, Journal of Dermatological Treatment 2024;35(1):2361106 — pooled RCT evidence that tranexamic acid significantly reduces melasma severity via plasmin-inhibition of UV-triggered melanogenesis

2024Meta-analysis — positivePMID:38843906View source ↗
MadecassosideModerate evidence6 citations

A purified compound from the cica (centella) plant, laser-focused on calming inflammation and speeding up how fast skin heals.

Liu L et al., Madecassoside Attenuated UVB Irradiation-Induced Skin Ferroptosis by Targeting POR, Phytomedicine 2026

2026Mechanism onlyPMID:41421280View source ↗

Bandopadhyay S et al., Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review, Journal of Cellular and Molecular Medicine 2023;27(5):593-608 — comprehensive review of wound-healing, anti-inflammatory and regenerative activity

2023Meta-analysis — positivePMID:36756687View source ↗

Park KS, Pharmacological Effects of Centella asiatica on Skin Diseases: Evidence and Possible Mechanisms, Evidence-Based Complementary and Alternative Medicine 2021;2021:5462633 — KR-authored review of triterpenes including madecassoside

2021Meta-analysis — positivePMID:34845411View source ↗
Vitamin CStrong evidence14 citations

Brightens dull skin and helps fade dark spots. Also defends against everyday UV and pollution damage when worn under sunscreen.

Pullar JM et al., The roles of vitamin C in skin health, Nutrients 2017;9(8):866 — concluded topical efficacy "poorly understood"; supports dietary vitamin C

2017Mechanism onlyPMID:28805671View source ↗

Lee JH et al., Effects of VitabridC12 on Skin Inflammation, Annals of Dermatology 2017

2017Mechanism onlyPMID:28966510View source ↗

MFDS Approved Functional Cosmetic Active — Ascorbic Acid and derivatives (whitening). Korean Ministry of Food and Drug Safety, Cosmetic Functional Active Ingredient List — L-ascorbic acid and stabilized derivatives (Magnesium Ascorbyl Phosphate, Ethyl Ascorbic Acid, Sodium Ascorbyl Phosphate) are approved whitening actives in the Korean Functional Cosmetics Codex; authorized concentrations documented in Jeon JS et al., International Journal of Cosmetic Science 2016;38(3):286-93 (PMID:26564311)

2016Regulatory approvalMFDS:AscorbicAcid-WhiteningView source ↗
+3 more ingredients
Lactobacillus FermentAnecdotal evidence4 citations

A "postbiotic" (dead probiotic bits) that talks to your skin microbiome without adding live bugs. Patches up a leaky barrier and is friendly even on very reactive skin.

Algieri F, Pimazzoni S et al. (Italy), Postbiotic derived from Lacticaseibacillus paracasei CNCM I-5220 as a novel approach to improve ageing-induced skin damage, Scientific Reports 2026 — 6-week topical postbiotic application reduced roughness and increased hydration, elasticity, and echogenicity vs placebo; boosted hyaluronic acid in keratinocytes and pro-collagen in fibroblasts

2026Positive — efficacyPMID:42168426View source ↗

Flores Rodriguez JC et al. (Mexico/Colombia/Costa Rica), Postbiotics in Dermatology: A Literature Review of Emerging Topical Therapies for Acne, Rosacea, and Eczema, Cureus 2026;18(3) — review of 16 studies: postbiotics improved SCORAD and barrier function in atopic dermatitis; reduced inflammatory acne lesions 50-70% and suppressed sebum 42-72%

2026Meta-analysis — positivePMID:42005241View source ↗

Effects of a lotion containing probiotic ferment lysate as the main functional ingredient on enhancing skin barrier: a randomized, self-control study, Scientific Reports 2023

2023Positive — efficacyPMID:37803101View source ↗
Centella AsiaticaModerate evidence9 citations

Also called "cica," it calms redness, repairs the skin barrier, and speeds up healing. The go-to for irritated or reactive skin.

Hur N et al., A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women, Nutrients 2026

2026Positive — efficacyPMID:42196964View source ↗

Borowicz KK et al., Geroprotective Potential of Centella asiatica: Modulation of Cellular Aging, Nutrients 2026

2026Mechanism onlyPMID:42280293View source ↗

Su Z et al., The Effectiveness and Safety of a Skin Care Product With Centella asiatica Leaf Extract, Ceramide NP, and Panthenol in Subjects With Sensitive Skin: A Prospective, Observational Study, Journal of Cosmetic Dermatology 2025;24(7):e70324 — Sun Yat-Sen U 4-week study; cream provided rapid relief of facial redness and supported barrier function

2025Positive — efficacyPMID:40682399View source ↗
NiacinamideStrong evidence11 citations

A multitasker that calms redness, evens out skin tone, and helps oily skin balance out. One of the safest do-a-little-of-everything ingredients.

Moro F et al., Skin Cancer Prevention and Antiaging: Role of Nicotinamide, International Journal of Molecular Sciences 2026

2026Mechanism onlyPMID:42278444View source ↗

Passeron T et al., An Investigator-Blinded, Randomized Trial of a Broad-Spectrum Sunscreen Containing Sclareolide and Niacinamide, Dermatology and Therapy (Heidelberg) 2026

2026Positive — efficacyPMID:41240206View source ↗

Vergilio MM et al., Topical Formulation with Niacinamide Combined with 5 MHz Ultrasound for Improving Skin Ageing, Current Medicinal Chemistry 2025

2025Positive — efficacyPMID:39171587View source ↗

Sources: PubMed · KCI · J-Stage · CNKI · Wanfang · SFD · MFDS · Cochrane · SCCS · CIR. Every entry points to a specific document. See methodology for what each outcome label means.

Layering conflicts

Ingredients in this product that can react with common actives. Avoid stacking unless noted.

  • Benzoyl peroxide breaks down vitamin C, making both less effective. Use one in the morning and the other at night.

  • Vitamin C and retinol work best at different pH levels. Use vitamin C in the morning and retinol at night.

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Not medical advice. GlowPal is educational. Patch-test new products and talk to a qualified healthcare professional before changing your routine, especially if you're pregnant, nursing, or have a diagnosed skin condition. See our terms.