Shop medicube Hyaluronic Multi Peptide PDRN Serum 30ml
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medicube

Hyaluronic Multi Peptide PDRN Serum 30ml

~$22· 30ml
AcneDark spotsFine lines & firmnessDryness

Evidence behind the ingredients

Real citations from our research database — one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

NiacinamideStrong evidence11 citations

A multitasker that calms redness, evens out skin tone, and helps oily skin balance out. One of the safest do-a-little-of-everything ingredients.

Moro F et al., Skin Cancer Prevention and Antiaging: Role of Nicotinamide, International Journal of Molecular Sciences 2026

2026Mechanism onlyPMID:42278444View source ↗

Passeron T et al., An Investigator-Blinded, Randomized Trial of a Broad-Spectrum Sunscreen Containing Sclareolide and Niacinamide, Dermatology and Therapy (Heidelberg) 2026

2026Positive — efficacyPMID:41240206View source ↗

Vergilio MM et al., Topical Formulation with Niacinamide Combined with 5 MHz Ultrasound for Improving Skin Ageing, Current Medicinal Chemistry 2025

2025Positive — efficacyPMID:39171587View source ↗
Hyaluronic AcidStrong evidence7 citations

A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.

Bravo B et al., Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence, Dermatology and Therapy 2022;12(12):2657-2680 — HA-based cosmeceuticals reliably improve hydration and signs of skin aging

2022Meta-analysis — positivePMID:36200921View source ↗

Lee SG et al., Hyaluronan Oligosaccharides Improve Rosacea-Like Phenotype through Anti-Inflammatory and Epidermal Barrier-Improving Effects, Annals of Dermatology 2020

2020Mechanism onlyPMID:33911737View source ↗

An JH et al., Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin, Annals of Dermatology 2019;31(3):263-271 — cross-linked HA microneedle patches improved wrinkles on Korean skin with minimal discomfort

2019Positive — efficacyPMID:33911590View source ↗
SqualaneModerate evidence7 citations

A lightweight oil that mimics what your skin already makes. Softens and seals in hydration without feeling greasy.

Wolosik K et al., Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast, Molecules 2025;30(9):1964 — low-dose squalane (0.005-0.015%) restored collagen biosynthesis and wound healing in UVA-exposed human dermal fibroblasts

2025Mechanism onlyPMID:40363772View source ↗

Morgan AB et al., Explicating the multifunctional roles of tocotrienol and squalene in promoting skin health, Skin Health and Disease 2024;4(5):e448 — squalene/squalane promotes skin health via antioxidant, hydrating, emollient, anti-inflammatory mechanisms

2024Mechanism onlyPMID:39355739View source ↗

Prakoeswa CRS et al. (Indonesia), The Role of Moisturizer Containing Anti-inflammatory on Skin Hydration in Mild-Moderate Atopic Dermatitis Patients, Dermatology Research and Practice 2024;2024:3586393 — multi-ingredient anti-inflammatory moisturizer (shea butter + bacterial lysate + allantoin + bisabolol + botanicals + squalane as one emollient among many) improved skin hydration over 14 days vs standard in AD patients. NOTE: result cannot be attributed to squalane alone

2024Positive — efficacyPMID:39741562View source ↗
+3 more ingredients
Matrixyl PeptidesModerate evidence6 citations

Signals your skin to make more collagen. Quiet but real support for firmness and fine lines with consistent daily use.

Yang Y et al., Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream, Skin Research and Technology 2024;30(7):e13790 — 12-week study of active complex containing Matrixyl 3000 peptides showed significant improvement in hydration, elasticity, periorbital wrinkles

2024Positive — efficacyPMID:38932444View source ↗

Lintner K, Gerstein F, Solish N, A serum containing vitamins C and E and a matrix-repair tripeptide reduces facial signs of aging as evidenced by Primos analysis, Journal of Cosmetic Dermatology 2020;19(12):3262-3269 — matrix-repair tripeptide serum: 8-9% roughness reduction, 9% redness reduction by Primos imaging

2020Positive — efficacyPMID:33103342View source ↗

Bae JS et al., Topical application of palmitoyl-RGD reduces human facial wrinkle formation in Korean women, Archives of Dermatological Research 2017;309(8):665-671 — palmitoylated peptide reduced wrinkle formation via collagen activation and protection from degradation

2017Positive — efficacyPMID:28752204View source ↗
PanthenolModerate evidence5 citations

Pro-vitamin B5. Deeply hydrates and helps repair the skin barrier, calming dry or compromised skin.

Gao Y et al., Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment, Journal of Cosmetic Dermatology 2025;24(7):e70223 — double-blind RCT (n=60): panthenol mask decreased erythema, enhanced hydration, repaired barrier vs saline

2025Positive — efficacyPMID:40613435View source ↗

Cho YS et al., Use of Dexpanthenol for Atopic Dermatitis-Benefits and Recommendations Based on Current Evidence, Journal of Clinical Medicine 2022;11(14):3943 — Korean-authored review; dexpanthenol improves barrier and reduces severity in mild-to-moderate AD

2022Meta-analysis — positivePMID:35887707View source ↗

Heise R et al., Accelerated wound healing with a dexpanthenol-containing ointment after fractional ablative CO2 laser resurfacing of photo-damaged skin in a randomized prospective clinical trial, Cutaneous and Ocular Toxicology 2019;38(3):274-278 — RCT: dexpanthenol significantly faster wound closure vs petroleum jelly post-laser

2019Positive — efficacyPMID:30897983View source ↗
AdenosineModerate evidence7 citations

A Korean-approved anti-wrinkle ingredient that encourages collagen production for a smoother, firmer look.

Nguyen NH et al., Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation, International Journal of Molecular Sciences 2026

2026Mechanism onlyPMID:42278371View source ↗

MFDS Approved Functional Cosmetic Active — Adenosine (anti-wrinkle). Korean Ministry of Food and Drug Safety, Cosmetic Functional Active Ingredient List

2020Regulatory approvalMFDS:Adenosine-AntiWrinkleView source ↗

Jang M et al., Dissolving microneedle with high molecular weight hyaluronic acid to improve skin wrinkles, dermal density and elasticity, International Journal of Cosmetic Science 2020;42(3):302-309 — Korean comparison: HMW HA + adenosine outperformed LMW HA across wrinkle and elasticity parameters

2020Positive — efficacyPMID:32421218View source ↗

Sources: PubMed · KCI · J-Stage · CNKI · Wanfang · SFD · MFDS · Cochrane · SCCS · CIR. Every entry points to a specific document. See methodology for what each outcome label means.

Layering conflicts

Ingredients in this product that can react with common actives. Avoid stacking unless noted.

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