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Shop CeraVe Skin Renewing Night Cream with Peptide Complex and Hyaluronic Acid (1.7 oz)
Moisturizer
CeraVe

Skin Renewing Night Cream with Peptide Complex and Hyaluronic Acid (1.7 oz)

~$15· 1.7oz
AcneDark spotsRednessVisible pores

What it's good for

Key actives from our research database. Click any to read the full evidence dossier.

  • CeramidesStrong evidenceFull dossier ↗

    Refills the natural barrier between your skin cells. Locks moisture in, keeps irritants out, calms dry or damaged skin.

    Good for: Barrier repair

  • NiacinamideStrong evidenceFull dossier ↗

    A multitasker that calms redness, evens out skin tone, and helps oily skin balance out. One of the safest do-a-little-of-everything ingredients.

    Good for: Brightening, Barrier repair, Anti-inflammatory

  • Hyaluronic AcidStrong evidenceFull dossier ↗

    A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.

    Good for: Hydrating

  • Vitamin EModerate evidenceFull dossier ↗

    A workhorse antioxidant that defends your skin from daily oxidative damage. Pairs especially well with vitamin C, and it's in nearly every good moisturizer for a reason.

    Good for: Antioxidant

  • AllantoinAnecdotal evidenceFull dossier ↗

    A gentle smoother and skin-soother. Reduces flakiness and helps the surface look more even.

    Good for: Anti-inflammatory, Hydrating

  • Shea ButterModerate evidenceFull dossier ↗

    A rich, naturally occlusive plant butter from the African karite tree. Soothes dry, irritation-prone skin, refills the lipid barrier, and was well tolerated enough in randomized trials that most participants used it comfortably as a daily emollient.

    Good for: Barrier repair, Hydrating, Anti-inflammatory

Evidence behind the ingredients

Real citations from our research database, one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

CeramidesStrong evidence7 citations

Refills the natural barrier between your skin cells. Locks moisture in, keeps irritants out, calms dry or damaged skin.

Andrew PV et al., Topical supplementation with physiological lipids rebalances the stratum corneum ceramide profile and strengthens skin barrier function in adults predisposed to atopic dermatitis, British Journal of Dermatology 2025;193(4):729-740 — physiological-lipid emulsion raised SC ceramide NP/AP and improved barrier function vs control

2025Positive (efficacy)PMID:40408261View source ↗

Nugroho WT, Sawitri, Astindari, Utomo B, Listiawan MY, Ervianti E, Astari L. The Efficacy of Moisturisers Containing Ceramide Compared with Other Moisturisers in the Management of Atopic Dermatitis: A Systematic Literature Review and Meta-Analysis. Indian J Dermatol. 2023;68(1):53-58. — Meta-analysis of 5 studies found ceramide-containing moisturisers produced significantly greater improvement in SCORAD compared with non-ceramide moisturisers in atopic dermatitis.

2023Meta-analysis (positive)PMID:37151263View source ↗

Shindo S et al., Effects of a moisturizer containing pseudo-ceramide and a eucalyptus extract on sweating function in adult atopic dermatitis: a double-blind, randomized, controlled left-right comparison clinical trial, Journal of Cosmetic Dermatology 2022;21(10):4503-4509 — pseudo-ceramide + eucalyptus moisturizer restored sweating function and barrier in AD adults

2022Positive (efficacy)PMID:35298858View source ↗
NiacinamideStrong evidence10 citations

A multitasker that calms redness, evens out skin tone, and helps oily skin balance out. One of the safest do-a-little-of-everything ingredients.

Moro F et al., Skin Cancer Prevention and Antiaging: Role of Nicotinamide, International Journal of Molecular Sciences 2026

2026Mechanism onlyPMID:42278444View source ↗

Passeron T et al., An Investigator-Blinded, Randomized Trial of a Broad-Spectrum Sunscreen Containing Sclareolide and Niacinamide, Dermatology and Therapy (Heidelberg) 2026

2026Positive (efficacy)PMID:41240206View source ↗

Vergilio MM et al., Topical Formulation with Niacinamide Combined with 5 MHz Ultrasound for Improving Skin Ageing, Current Medicinal Chemistry 2025

2025Positive (efficacy)PMID:39171587View source ↗
Hyaluronic AcidStrong evidence7 citations

A pure hydrator that holds water in your skin. Makes skin look plumper and smoother almost immediately.

Karabat MU, Tuncer MC. Effects of hyaluronic acid on skin at the cellular level: a systematic review. Rev Assoc Med Bras. 2025;71(8):e20250208. — Systematic review of 45 studies found low-molecular-weight HA stimulates keratinocyte proliferation and migration while high-molecular-weight HA drives skin hydration, supporting topical HA as an effective skin-hydrating and barrier-supporting ingredient.

2025Meta-analysis (positive)PMID:40990743View source ↗

Bravo B et al., Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence, Dermatology and Therapy 2022;12(12):2657-2680 — HA-based cosmeceuticals reliably improve hydration and signs of skin aging

2022Meta-analysis (positive)PMID:36200921View source ↗

Lee SG et al., Hyaluronan Oligosaccharides Improve Rosacea-Like Phenotype through Anti-Inflammatory and Epidermal Barrier-Improving Effects, Annals of Dermatology 2020

2020Mechanism onlyPMID:33911737View source ↗
+3 more ingredients
Vitamin EModerate evidence6 citations

A workhorse antioxidant that defends your skin from daily oxidative damage. Pairs especially well with vitamin C, and it's in nearly every good moisturizer for a reason.

Neves JR et al., Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs, Journal of Cosmetic Dermatology 2022;21(10):4462-4469 — tocopherol-containing antioxidant serum reduced pollution-induced damage and improved aging signs

2022Positive (efficacy)PMID:35150043View source ↗

Warshaw EM et al., Patch Testing With Tocopherol and Tocopherol Acetate: The North American Contact Dermatitis Group Experience, 2001 to 2016, Dermatitis 2021;32(5):308-318 — 15-year NACDG data: positive patch-test reactions to tocopherol rare given widespread cosmetic use

2021Safety assessmentPMID:34238818View source ↗

Lin FH et al., Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin, Journal of Investigative Dermatology 2005;125(4):826-832 — ferulic acid + vit C + vit E combo doubled photoprotection vs C+E alone (cross-listed; same paper cited for Ferulic Acid and Vit C)

2005Positive (efficacy)PMID:16185284View source ↗
AllantoinAnecdotal evidence6 citations

A gentle smoother and skin-soother. Reduces flakiness and helps the surface look more even.

Xu Z et al., Efficacy and Safety of Topical Compound Heparin Sodium Allantoin Gel for the Treatment of Rosacea, Journal of Cosmetic Dermatology 2025;24(4):e70129 — RCT (n=82, 12 weeks): allantoin gel improved erythema and alleviated itching/burning vs traditional therapy

2025Positive (efficacy)PMID:40177799View source ↗

Tan C et al., The combination of allantoin, bisabolol, D-panthenol and dipotassium glycyrrhizinate mitigates UVB-induced PGE2 synthesis by keratinocytes, International Journal of Cosmetic Science 2024;46(5):691-701 — in vitro: allantoin combination reduced UVB-induced PGE2, IL-1α, IL-6, IL-8, TNFα

2024Mechanism onlyPMID:38433250View source ↗

Saucedo-Acuna RA et al. (Mexico), Characterization and In Vivo Assay of Allantoin-Enriched Pectin Hydrogel for the Treatment of Skin Wounds, International Journal of Molecular Sciences 2023;24(8):7377 — allantoin-pectin hydrogel reduced wound healing time by ~71% with complete closure at day 15 in rat model

2023Mechanism onlyPMID:37108540View source ↗
Shea ButterModerate evidence4 citations

A rich, naturally occlusive plant butter from the African karite tree. Soothes dry, irritation-prone skin, refills the lipid barrier, and was well tolerated enough in randomized trials that most participants used it comfortably as a daily emollient.

O'Connor RJ et al., Clinical Evaluation of a Diaper Containing a Shea Butter-Based Emollient and Impact on Diapered Skin Erythema, Pediatr Dermatol 2025;42(3):532-538 — RCT n=271 infants, shea-butter diaper reduced dermatitis

2025Positive (efficacy)PMID:40189822View source ↗

Burnett CL, Bergfeld WF, Belsito DV, et al. Safety Assessment of Butyrospermum parkii (Shea)-Derived Ingredients as Used in Cosmetics. Cosmetic Ingredient Review Expert Panel Final Report.

2024Safety assessmentDOI:10.1177/10915818231224230View source ↗

Verallo-Rowell VM, Katalbas SS, Pangasinan JP. Natural (Mineral, Vegetable, Coconut, Essential) Oils and Contact Dermatitis. Curr Allergy Asthma Rep. 2016;16(7):51. — discussing shea butter unsaponifiable fraction NF-kB inhibition and dermatologic use.

2016Mechanism onlyPMID:27373890View source ↗

Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.

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