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Moisturizer
Acure

Day Cream

~$35· 1.7 Fl Oz (Pack of 2)

What it's good for

Key actives from our research database. Click any to read the full evidence dossier.

  • Aloe VeraModerate evidenceFull dossier ↗

    Calms irritation and adds light hydration. The classic for sunburned or reactive skin.

    Good for: Anti-inflammatory, Hydrating

  • Argan OilModerate evidenceFull dossier ↗

    The Moroccan kitchen-staple oil with real cosmetic data behind it. Daily use measurably improves skin elasticity in postmenopausal women. Good for dry, mature, or barrier-compromised skin without feeling greasy.

    Good for: Hydrating, Barrier repair, Antioxidant

  • CalendulaModerate evidenceFull dossier ↗

    A botanical with real clinical wins for irritated, post-procedure, or recovering skin, with randomized-trial support behind its soothing reputation. Gentle enough for delicate, easily reactive skin and dry, sensitive patches.

    Good for: Anti-inflammatory

  • Centella AsiaticaModerate evidenceFull dossier ↗

    Also called "cica," it calms redness, repairs the skin barrier, and speeds up recovery. The go-to for irritated or reactive skin.

    Good for: Anti-inflammatory, Barrier repair

  • ChamomileModerate evidenceFull dossier ↗

    The classic "tea-bag-on-puffy-eyes" botanical. Calms angry skin via well-studied anti-inflammatory pathways, gently. Good for reactive or rosacea-prone complexions.

    Good for: Anti-inflammatory, Antioxidant

  • Coenzyme Q10Moderate evidenceFull dossier ↗

    A naturally-occurring antioxidant your skin loses as you age. Topical CoQ10 restores some of what time depletes, supporting energy production in skin cells and softening wrinkle depth.

    Good for: Antioxidant, Anti-aging

  • GlycerinModerate evidenceFull dossier ↗

    A workhorse hydrator that pulls water into your skin. In nearly every good moisturizer for a reason.

    Good for: Hydrating

Evidence behind the ingredients

Real citations from our research database, one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

Aloe VeraModerate evidence7 citations

Calms irritation and adds light hydration. The classic for sunburned or reactive skin.

Huang YN et al., Effects of Aloe vera on Burn Injuries: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Journal of Burn Care & Research 2024;45(6):1536-1545 — topical aloe vera reduced burn wound-healing time

2024Meta-analysis (positive)PMID:38605441View source ↗

Tungkasamit T et al., Reduction in severity of radiation-induced dermatitis in head and neck cancer patients treated with topical aloe vera gel: A randomized multicenter double-blind placebo-controlled trial, European Journal of Oncology Nursing 2022;59:102164 — aloe vera reduced severity of moderate-to-severe radiation dermatitis

2022Positive (efficacy)PMID:35767935View source ↗

Sharma S et al., Second-Degree Burns and Aloe Vera: A Meta-analysis and Systematic Review, Advances in Skin & Wound Care 2022;35(11):1-9 — topical aloe vera shortened time to healing for second-degree burns

2022Meta-analysis (positive)PMID:36264753View source ↗
Argan OilModerate evidence4 citations

The Moroccan kitchen-staple oil with real cosmetic data behind it. Daily use measurably improves skin elasticity in postmenopausal women. Good for dry, mature, or barrier-compromised skin without feeling greasy.

Lin TK, Zhong L, Santiago JL, Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils, International Journal of Molecular Sciences 2017;19(1):70 — review of 19 plant oils including argan: documents anti-inflammatory, antioxidant, stratum-corneum barrier-repair mechanisms

2017Mechanism onlyPMID:29280987View source ↗

Boucetta KQ et al., The effect of dietary and/or cosmetic argan oil on postmenopausal skin elasticity, Clinical Interventions in Aging 2015;10:339-349 — 60-day RCT: both dietary and topical argan oil significantly increased cutometer-measured gross, net, and biological elasticity (all p<0.001) vs olive oil control

2015Positive (efficacy)PMID:25673976View source ↗

Boucetta KQ et al., Skin hydration in postmenopausal women: argan oil benefit with oral and/or topical use, Przeglad Menopauzalny 2014;13(5):280-288 — RCT; topical forearm application over 60 days significantly improved skin hydration

2014Positive (efficacy)PMID:26327867View source ↗
CalendulaModerate evidence6 citations

A botanical with real clinical wins for irritated, post-procedure, or recovering skin, with randomized-trial support behind its soothing reputation. Gentle enough for delicate, easily reactive skin and dry, sensitive patches.

Deligiannidou GE et al. (Greece), An Update of Phytotherapeutic Advances of Marigold (Calendula officinalis L.) in Wound Healing, Plants (Basel) 2025 — peer-reviewed review of 2020-2025 experimental and clinical evidence on Calendula formulations for skin regeneration: healing rate, cell proliferation, inflammatory modulation

2025Meta-analysis (positive)PMID:41304647View source ↗

Effect of oral Calendula officinalis on second-degree burn wound healing (Iran), Scars Burns and Healing 2023

2023Positive (efficacy)PMID:36632430View source ↗

Siddiquee S et al., Efficacy of topical Calendula officinalis on prevalence of radiation-induced dermatitis: A randomised controlled trial, Australasian Journal of Dermatology 2021;62(1):e35-e40 — topical calendula reduced radiation-induced dermatitis

2021Positive (efficacy)PMID:32965030View source ↗
+4 more ingredients
Centella AsiaticaModerate evidence6 citations

Also called "cica," it calms redness, repairs the skin barrier, and speeds up recovery. The go-to for irritated or reactive skin.

Hur N et al., A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women, Nutrients 2026

2026Positive (efficacy)PMID:42196964View source ↗

Borowicz KK et al., Geroprotective Potential of Centella asiatica: Modulation of Cellular Aging, Nutrients 2026

2026Mechanism onlyPMID:42280293View source ↗

Witkowska K et al., Topical Application of Centella asiatica in Wound Healing: Recent Insights into Mechanisms and Clinical Efficacy, Pharmaceutics 2024;16(10):1252 — modern hydrogel and nanostructured Centella delivery systems accelerate wound healing across wound types

2024Meta-analysis (positive)PMID:39458583View source ↗
ChamomileModerate evidence6 citations

The classic "tea-bag-on-puffy-eyes" botanical. Calms angry skin via well-studied anti-inflammatory pathways, gently. Good for reactive or rosacea-prone complexions.

Essential Oil of Matricaria chamomilla Alleviates Psoriatic-Like Skin Inflammation by Inhibiting PI3K/Akt/mTOR and p38MAPK Signaling Pathway, Clinical Cosmetic and Investigational Dermatology 2024

2024Mechanism onlyPMID:38222858View source ↗

Comparative analysis of whole plant, flower and root extracts of Chamomilla recutita L. (Germany), Frontiers in Immunology 2024

2024Mechanism onlyPMID:38720895View source ↗

Xu J et al., Therapeutic effects of chamomile volatile oil nanoemulsion/Bletilla striata polysaccharides gels on atopic dermatitis, International Journal of Biological Macromolecules 2024 — topical chamomile volatile oil nanoemulsion (19.07 nm) reduced skin damage, epidermal thickness, and mast cell infiltration in atopic dermatitis mice; rebalanced Th1/Th2

2024Positive (efficacy)PMID:39111460View source ↗
Coenzyme Q10Moderate evidence5 citations

A naturally-occurring antioxidant your skin loses as you age. Topical CoQ10 restores some of what time depletes, supporting energy production in skin cells and softening wrinkle depth.

Li S et al., Ginsenoside Nanoliposomes Deliver Ergothioneine and Coenzyme Q10 to Address Skin Aging via Mitochondrial Mechanisms, Colloids and Surfaces B: Biointerfaces 2026

2026Mechanism onlyPMID:41475077View source ↗

Lain ET, Agrawal N, Ruvolo E, Weise JM, Callender VD, The Role of Coenzyme Q10 in Skin Aging and Opportunities for Topical Intervention: A Review, Journal of Clinical and Aesthetic Dermatology 2024;17(8):42-47

2024Positive (efficacy)PMID:39148958View source ↗

Ayunin Q, Miatmoko A, Soeratri W, Erawati T, Susanto J, Legowo D, Improving the anti-ageing activity of coenzyme Q10 through protransfersome-loaded emulgel, Scientific Reports 2022;12(1):906 — topical CoQ10 protransfersomal emulgel increased collagen density and fibroblast count in UV-aged mouse skin

2022Positive (efficacy)PMID:35042910View source ↗
GlycerinModerate evidence6 citations

A workhorse hydrator that pulls water into your skin. In nearly every good moisturizer for a reason.

Danby SG et al., Different types of emollient cream exhibit diverse physiological effects on the skin barrier in adults with atopic dermatitis, Clinical and Experimental Dermatology 2022;47(6):1154-1164 — glycerol+urea emollient delivered superior barrier-strengthening and irritant protection

2022Positive (efficacy)PMID:35167133View source ↗

Youssef R et al., Glycerol 85% efficacy on atopic skin and its microbiome: a randomized controlled trial, Journal of Dermatological Treatment 2021;32(7):730-736 — topical glycerol 85% RCT on atopic skin

2021Positive (efficacy)PMID:31869257View source ↗

Evans NJ et al., Human axillary skin condition is improved following incorporation of glycerol into the stratum corneum from an antiperspirant formulation, Archives of Dermatological Research 2017;309(9):739-748 — 4% glycerol penetrated axillary SC, reduced irritation, improved hydration

2017Positive (efficacy)PMID:28889318View source ↗

Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.

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