Ingredients Anti-inflammatory Calendula
72Cd
Tier · Moderate evidence
Anti-inflammatory

Calendula

INCI: Calendula Officinalis Flower Extract · Also called: Marigold, Calendula Officinalis

A botanical with real clinical wins for irritated, post-procedure, or healing skin, including faster cesarean-wound closure in a randomized trial. Gentle enough for diaper rash; useful for eczema flares.

For your skin

A botanical with real clinical wins for irritated, post-procedure, or healing skin, including faster cesarean-wound closure in a randomized trial. Gentle enough for diaper rash; useful for eczema flares.

Want the science? Keep reading ↓

Mechanism of action

Marigold flower extract rich in triterpenoids (faradiol esters) and flavonoids that accelerate fibroblast migration, granulation tissue formation, and re-epithelialization in clinical wound trials.

Why we tier this moderate

5 cited papers across 3 countries. The mechanism is well-described and there's at least one controlled trial in the literature, but we tier this Moderate rather than Strong to stay honest about how many specific papers we cite directly.

3
International
1
European Union
1
United States

Cited research

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Ozturan YA, Akin I (Turkey), Calendula officinalis extract enhances wound healing by promoting fibroblast activity and reducing inflammation in mice, Cutaneous and Ocular Toxicology 2025 — 5% topical aqueous Calendula extract over 14 days improved full-thickness skin wound closure, fibroblast activity, growth factors, and reduced inflammation markers in BALB/c mice

2025Positive — efficacyPMID:40173007View source ↗
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Deligiannidou GE et al. (Greece), An Update of Phytotherapeutic Advances of Marigold (Calendula officinalis L.) in Wound Healing, Plants (Basel) 2025 — peer-reviewed review of 2020-2025 experimental and clinical evidence on Calendula formulations for skin regeneration: healing rate, cell proliferation, inflammatory modulation

2025Meta-analysis — positivePMID:41304647View source ↗
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Effect of oral Calendula officinalis on second-degree burn wound healing (Iran), Scars Burns and Healing 2023

2023Positive — efficacyPMID:36632430View source ↗
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Givol O et al., A systematic review of Calendula officinalis extract for wound healing, Wound Repair and Regeneration 2019

2019Meta-analysis — positivePMID:31145533View source ↗
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Jahdi F et al. (Iran), The impact of calendula ointment on cesarean wound healing: A randomized controlled clinical trial, Journal of Family Medicine and Primary Care 2018;7(5):893-897

2018Positive — efficacyPMID:30598929View source ↗

Sources: PubMed · KCI · J-Stage · CNKI · Wanfang · SFD · MFDS · Cochrane · SCCS · CIR. Every entry points to a specific document. See methodology for what each outcome label means.