CICA Reedle Shot 100
- Routine step
- Serum (ampoule)
- When
- Morning and evening
- Skin types
- Normal, Combination, Oily
- Pairs well with
- Madecassoside, Heartleaf, Niacinamide, Azelaic Acid
Apply a pea-sized amount to clean, slightly damp skin before your moisturizer. Start with a few nights a week if it contains an active you are new to.
This product contains an active that can irritate at first. Patch test on the inner forearm for 24 hours and start two or three times a week.
Ingredient research in this formula
These are ingredient-level research links, not evidence that this exact product has been clinically tested.
Also called "cica," it calms redness, repairs the skin barrier, and speeds up recovery. The go-to for irritated or reactive skin.
Good for: Anti-inflammatory, Barrier repair
Liquid microneedling in a bottle. It causes a temporary prickly sensation but creates tiny pathways in your skin so all your other expensive serums can actually penetrate deeper.
Good for: Exfoliating, Anti-aging
Evidence behind the ingredients
Real citations from our research database, one per tracked active in this product. Click any ingredient name to read its full evidence dossier.
Also called "cica," it calms redness, repairs the skin barrier, and speeds up recovery. The go-to for irritated or reactive skin.
Hur N et al., A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women, Nutrients 2026
Borowicz KK et al., Geroprotective Potential of Centella asiatica: Modulation of Cellular Aging, Nutrients 2026
Witkowska K et al., Topical Application of Centella asiatica in Wound Healing: Recent Insights into Mechanisms and Clinical Efficacy, Pharmaceutics 2024;16(10):1252: modern hydrogel and nanostructured Centella delivery systems accelerate wound healing across wound types
Liquid microneedling in a bottle. It causes a temporary prickly sensation but creates tiny pathways in your skin so all your other expensive serums can actually penetrate deeper.
He W, Zhang C, Lai H, Wu G, Xiong M, Peng H, Chen M, Wang KJ, The topical application of Sphistin(12-38) in combination with sponge spicules for the acne treatment, Drug Delivery and Translational Research 2025: sponge spicules increased skin penetration of an antimicrobial peptide about 6-fold; combination cured 100% of rabbit-ear acne in vivo over 2 weeks (animal/penetration mechanism)
Jin Y, Zhang C, Jia M, Chen M, Enhanced Dermal Delivery of Nanoparticulate Formulation of Cutibacterium acnes Using Sponge Spicules for Atopic Dermatitis Treatment, International Journal of Nanomedicine 2025: Haliclona sp. sponge spicules enhanced dermal delivery of a nanoparticulate formulation (delivery mechanism, preclinical)
Zhang C et al., Topical Delivery of Lidocaine Using Spicules for Local Anesthesia, Drug Delivery and Translational Research 2025
Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.
Similar comparisons
Not medical advice. GlowPal is educational. Patch-test new products and talk to a qualified healthcare professional before changing your routine, especially if you're pregnant, nursing, or have a diagnosed skin condition. See our terms.