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Shop Sunday Riley A+ High-Dose Retinoid Serum
Treatment
Sunday Riley

A+ High-Dose Retinoid Serum

~$50· 15mlPM only
Fine lines & firmnessDark spotsUneven texture

What it's good for

Key actives from our research database. Click any to read the full evidence dossier.

  • RetinolStrong evidenceFull dossier ↗

    Speeds up how fast your skin renews itself so old, dull cells shed faster and fresher skin shows through. Builds collagen over time, smoothing fine lines.

    Good for: Anti-aging

  • BakuchiolModerate evidenceFull dossier ↗

    A plant-based alternative to retinol. Smooths fine lines and evens tone with much less irritation, making it safer for sensitive skin.

    Good for: Anti-aging

  • HoneyModerate evidenceFull dossier ↗

    An ancient humectant and antimicrobial ingredient with a long research track record. Its sugar matrix and flavonoids help draw in moisture and support skin comfort; formulas pairing honey with beeswax and olive oil have shown improvement in dry, irritation-prone skin in controlled trials.

    Good for: Anti-inflammatory, Anti-acne, Hydrating

New to this? Patch test on your inner arm for 24 to 48 hours before applying to your face. If you have sensitive skin or rosacea, start 2 to 3 times per week and build up slowly.

Evidence behind the ingredients

Real citations from our research database, one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

RetinolStrong evidence11 citations

Speeds up how fast your skin renews itself so old, dull cells shed faster and fresher skin shows through. Builds collagen over time, smoothing fine lines.

SCCS Revision of the Scientific Opinion on Vitamin A (Retinol, Retinyl Acetate, Retinyl Palmitate), SCCS/1639/21, final version adopted 24-25 October 2022

2022Safety assessmentSCCS/1639/21View source ↗

Chien AL et al. Biomarkers of Tretinoin Precursors and Tretinoin Efficacy in Patients With Moderate to Severe Facial Photodamage: A Randomized Clinical Trial. JAMA Dermatology. 2022;158(8):892-900. doi:10.1001/jamadermatol.2022.1891 — RCT comparing topical retinol precursors vs tretinoin for photoaging; both showed equivalent wrinkle reduction at week 24 with retinol formulation causing 6x less erythema than tretinoin.

2022Positive (efficacy)PMID:35675051View source ↗

MFDS Approved Functional Cosmetic Active — Retinol (anti-wrinkle). Korean Ministry of Food and Drug Safety, Cosmetic Functional Active Ingredient List — listed alongside Adenosine, Retinyl Palmitate, and Polyethoxylated Retinamide in the Korean Functional Cosmetics Codex anti-wrinkle category

2020Regulatory approvalMFDS:Retinol-AntiWrinkleView source ↗
BakuchiolModerate evidence6 citations

A plant-based alternative to retinol. Smooths fine lines and evens tone with much less irritation, making it safer for sensitive skin.

Fanning N et al., Human Clinical Trials Using Topical Bakuchiol Formulations for the Treatment of Skin Disorders: A Systematic Review, Journal of Drugs in Dermatology 2024;23(4):239-243 — bakuchiol trials suggest efficacy but are methodologically limited (mostly uncontrolled, combination formulations)

2024Meta-analysis (mixed)PMID:38564402View source ↗

Hu L et al., Effect and Mechanism of Tricholoma matsutake Extract Combined with Bakuchiol and Ergothioneine on UVB-Induced Skin Aging, Journal of Cosmetic Dermatology 2024

2024Mechanism onlyPMID:39014903View source ↗

Puyana C et al., Applications of Bakuchiol in Dermatology: Systematic Review of the Literature, Journal of Cosmetic Dermatology 2022

2022Meta-analysis (positive)PMID:36176207View source ↗
HoneyModerate evidence5 citations

An ancient humectant and antimicrobial ingredient with a long research track record. Its sugar matrix and flavonoids help draw in moisture and support skin comfort; formulas pairing honey with beeswax and olive oil have shown improvement in dry, irritation-prone skin in controlled trials.

Semprini A, Braithwaite I, Corin A, et al. Randomised controlled trial of topical kanuka honey for the treatment of acne. BMJ Open. 2016 Feb 1;6(2):e009448. — RCT: kanuka honey + antibacterial soap was NOT significantly more effective than antibacterial soap alone for acne; primary endpoint not met.

2016InconclusivePMID:26832428View source ↗

Jull AB, Cullum N, Dumville JC, Westby MJ, Deshpande S, Walker N. Honey as a topical treatment for wounds. Cochrane Database Syst Rev. 2015;(3):CD005083.

2015Meta-analysis (mixed)PMID:25742878View source ↗

Mandal MD, Mandal S. Honey: its medicinal property and antibacterial activity. Asian Pac J Trop Biomed. 2011;1(2):154-160.

2011Mechanism onlyPMID:23569748View source ↗

Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.

Full ingredient list

Everything on the package label, not just the tracked actives above.

Fragrance freeSulfates freeParabens free
  • Contains drying alcohol: AlcoholWorth knowing if you have sensitive or reactive skin.
  • Contains silicones: Dimethicone, Disiloxane, Cetyl PEG/​PPG-10/​1 Dimethicone, Phenyl Trimethicone, Polysilicone-11No irritancy evidence. CIR rates this safe as used; some shoppers avoid it by preference.
+Show all 55 ingredients

Listed in the order printed on the package. By regulation, ingredients at 1% or higher are listed in descending order by concentration, so the first entry is the largest part of the formula.

  1. Water/​Eau/​Aqua
  2. Propanediol
  3. Dimethyl Isosorbide
  4. Triheptanoin
  5. Dimethicone
  6. Glycerin
  7. Pentylene Glycol
  8. Hexyldecanol
  9. Disiloxane
  10. Cetyl PEG/​PPG-10/​1 Dimethicone
  11. Diheptyl Succinate
  12. Propylene Carbonate
  13. Hydroxypinacolone Retinoate 0.5%
  14. PPG-24-Glycereth-24
  15. Phenyl Trimethicone
  16. Retinol
  17. Ubiquinone (Coq10)
  18. Honey Extract
  19. Sodium Hyaluronate Crosspolymer
  20. Algae Extract
  21. Zingiber Officinale (Ginger) Extract
  22. Opuntia Ficus-Indica Fruit Extract
  23. Bisabolol
  24. Butyrospermum Parkii (Shea) Butter
  25. Phospholipids
  26. Saccharomyces Cerevisiae Extract
  27. Lecithin
  28. Sodium Acrylates Copolymer
  29. Hydrogenated Polyisobutene
  30. 1,2-Hexanediol
  31. 4-T- Butylcyclohexanol
  32. Polyglyceryl-10 Stearate
  33. Caprylyl Glycol
  34. Helianthus Annuus Seed Oil
  35. Sorbitol
  36. Cetylhydroxyproline Palmitamide
  37. Polysilicone-11
  38. Benzoic Acid
  39. Dehydroacetic Acid
  40. Sodium Phytate
  41. Glyceryl Polyacrylate
  42. Polysorbate
  43. Hydroxyphenyl Propamidobenzoic Acid
  44. Stearic Acid
  45. Brassica Campestris Sterols
  46. PVP
  47. Capryloyl Glycerin/​Sebacic Acid Copolymer
  48. Sodium Benzoate
  49. Alcohol
  50. Potassium Phosphate
  51. Decyl Glucoside
  52. Phenoxyethanol
  53. Hexylene Glycol
  54. Potassium Sorbate
  55. Tocopherol

Layering conflicts

Ingredients in this product that can react with common actives. Avoid stacking unless noted.

  • Retinol + salicylic acid can over-exfoliate and damage the barrier. Alternate nights.

  • Retinol + glycolic acid is a classic barrier-buster. Use on different nights.

  • Retinol + lactic acid is gentler than glycolic but still alternate nights to be safe.

  • Retinol + mandelic acid — alternate nights to preserve barrier integrity.

  • Benzoyl peroxide can break down retinol. Use one in the morning and the other at night, or pick a stabilized formula made to combine them.

  • Vitamin C and retinol work best at different pH levels. Use vitamin C in the morning and retinol at night.

Similar comparisons

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Not medical advice. GlowPal is educational. Patch-test new products and talk to a qualified healthcare professional before changing your routine, especially if you're pregnant, nursing, or have a diagnosed skin condition. See our terms.