Azulene Ampoule
What it's good for
Key actives from our research database. Click any to read the full evidence dossier.
Also called "cica," it calms redness, repairs the skin barrier, and speeds up recovery. The go-to for irritated or reactive skin.
Good for: Anti-inflammatory, Barrier repair
Refills the natural barrier between your skin cells. Locks moisture in, keeps irritants out, calms dry or damaged skin.
Good for: Barrier repair
The classic "tea-bag-on-puffy-eyes" botanical. Calms angry skin via well-studied anti-inflammatory pathways, gently. Good for reactive or rosacea-prone complexions.
Good for: Anti-inflammatory, Antioxidant
The third (and most often missing) lipid in the skin barrier triumvirate. Without it, even ceramide-heavy creams underperform. Topping it up is what lets compromised, aged, or eczema-prone skin actually rebuild its waterproof layer.
Good for: Barrier repair
A polyphenol from green tea that calms UV-triggered redness and reinforces your sunscreen as a second line of antioxidant defense.
Good for: Antioxidant, Anti-inflammatory, Sun protection
A workhorse hydrator that pulls water into your skin. In nearly every good moisturizer for a reason.
Good for: Hydrating
A rich, naturally occlusive plant butter from the African karite tree. Soothes dry, irritation-prone skin, refills the lipid barrier, and was well tolerated enough in randomized trials that most participants used it comfortably as a daily emollient.
Good for: Barrier repair, Hydrating, Anti-inflammatory
A lightweight oil that mimics what your skin already makes. Softens and seals in hydration without feeling greasy.
Good for: Barrier repair, Hydrating
Evidence behind the ingredients
Real citations from our research database, one per tracked active in this product. Click any ingredient name to read its full evidence dossier.
Also called "cica," it calms redness, repairs the skin barrier, and speeds up recovery. The go-to for irritated or reactive skin.
Hur N et al., A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women, Nutrients 2026
Borowicz KK et al., Geroprotective Potential of Centella asiatica: Modulation of Cellular Aging, Nutrients 2026
Witkowska K et al., Topical Application of Centella asiatica in Wound Healing: Recent Insights into Mechanisms and Clinical Efficacy, Pharmaceutics 2024;16(10):1252 — modern hydrogel and nanostructured Centella delivery systems accelerate wound healing across wound types
Refills the natural barrier between your skin cells. Locks moisture in, keeps irritants out, calms dry or damaged skin.
Andrew PV et al., Topical supplementation with physiological lipids rebalances the stratum corneum ceramide profile and strengthens skin barrier function in adults predisposed to atopic dermatitis, British Journal of Dermatology 2025;193(4):729-740 — physiological-lipid emulsion raised SC ceramide NP/AP and improved barrier function vs control
Nugroho WT, Sawitri, Astindari, Utomo B, Listiawan MY, Ervianti E, Astari L. The Efficacy of Moisturisers Containing Ceramide Compared with Other Moisturisers in the Management of Atopic Dermatitis: A Systematic Literature Review and Meta-Analysis. Indian J Dermatol. 2023;68(1):53-58. — Meta-analysis of 5 studies found ceramide-containing moisturisers produced significantly greater improvement in SCORAD compared with non-ceramide moisturisers in atopic dermatitis.
Shindo S et al., Effects of a moisturizer containing pseudo-ceramide and a eucalyptus extract on sweating function in adult atopic dermatitis: a double-blind, randomized, controlled left-right comparison clinical trial, Journal of Cosmetic Dermatology 2022;21(10):4503-4509 — pseudo-ceramide + eucalyptus moisturizer restored sweating function and barrier in AD adults
The classic "tea-bag-on-puffy-eyes" botanical. Calms angry skin via well-studied anti-inflammatory pathways, gently. Good for reactive or rosacea-prone complexions.
Essential Oil of Matricaria chamomilla Alleviates Psoriatic-Like Skin Inflammation by Inhibiting PI3K/Akt/mTOR and p38MAPK Signaling Pathway, Clinical Cosmetic and Investigational Dermatology 2024
Comparative analysis of whole plant, flower and root extracts of Chamomilla recutita L. (Germany), Frontiers in Immunology 2024
Xu J et al., Therapeutic effects of chamomile volatile oil nanoemulsion/Bletilla striata polysaccharides gels on atopic dermatitis, International Journal of Biological Macromolecules 2024 — topical chamomile volatile oil nanoemulsion (19.07 nm) reduced skin damage, epidermal thickness, and mast cell infiltration in atopic dermatitis mice; rebalanced Th1/Th2
+−5 more ingredients
The third (and most often missing) lipid in the skin barrier triumvirate. Without it, even ceramide-heavy creams underperform. Topping it up is what lets compromised, aged, or eczema-prone skin actually rebuild its waterproof layer.
Sugarman JL, Parish LC. Efficacy of a lipid-based barrier repair formulation in moderate-to-severe pediatric atopic dermatitis. J Drugs Dermatol. 2009;8(12):1106-1111. — ceramide/cholesterol/fatty-acid triple-lipid formulation reduced disease severity, pruritus and improved sleep at days 14 and 28.
Chamlin SL, Kao J, Frieden IJ, Sheu MY, Fowler AJ, Fluhr JW, Williams ML, Elias PM. Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity. J Am Acad Dermatol. 2002;47(2):198-208. — physiologic ceramide:cholesterol:fatty-acid lipid mixture; SCORAD improved significantly in 22 of 24 patients.
Zettersten EM, Ghadially R, Feingold KR, Crumrine D, Elias PM. Optimal ratios of topical stratum corneum lipids improve barrier recovery in chronologically aged skin. J Am Acad Dermatol. 1997;37(3 Pt 1):403-408.
A polyphenol from green tea that calms UV-triggered redness and reinforces your sunscreen as a second line of antioxidant defense.
Detudom P, Kamanamool N, Paichitrojjana A, Udompataikul P, Udompataikul M, Efficacy of anti-sebum moisturizing cream containing 2% l-carnitine and 5% epigallocatechin gallate in seborrhea, Journal of Cosmetic Dermatology 2023;22(11):3058-3064 — Thai RCT showed EGCG-containing cream significantly reduced sebum and improved hydration in seborrhea
Ud-Din S et al., A Double-Blind, Randomized Trial Shows the Role of Zonal Priming and Direct Topical Application of Epigallocatechin-3-Gallate in the Modulation of Cutaneous Scarring in Human Skin, Journal of Investigative Dermatology 2019;139(8):1680-1690 — topical EGCG reduced scar thickness weeks 1-3 and increased elasticity at week 4 vs placebo
Kim YR et al., Clinical Evaluation of a New-Formula Shampoo for Scalp Seborrheic Dermatitis Containing Rosa centifolia + EGCG: A Randomized Double-Blind Controlled Study, Annals of Dermatology 2014;26(6):733-8 — EGCG-containing shampoo matched ketoconazole and zinc pyrithione efficacy; faster erythema response than 1% zinc pyrithione
A workhorse hydrator that pulls water into your skin. In nearly every good moisturizer for a reason.
Danby SG et al., Different types of emollient cream exhibit diverse physiological effects on the skin barrier in adults with atopic dermatitis, Clinical and Experimental Dermatology 2022;47(6):1154-1164 — glycerol+urea emollient delivered superior barrier-strengthening and irritant protection
Youssef R et al., Glycerol 85% efficacy on atopic skin and its microbiome: a randomized controlled trial, Journal of Dermatological Treatment 2021;32(7):730-736 — topical glycerol 85% RCT on atopic skin
Evans NJ et al., Human axillary skin condition is improved following incorporation of glycerol into the stratum corneum from an antiperspirant formulation, Archives of Dermatological Research 2017;309(9):739-748 — 4% glycerol penetrated axillary SC, reduced irritation, improved hydration
A rich, naturally occlusive plant butter from the African karite tree. Soothes dry, irritation-prone skin, refills the lipid barrier, and was well tolerated enough in randomized trials that most participants used it comfortably as a daily emollient.
O'Connor RJ et al., Clinical Evaluation of a Diaper Containing a Shea Butter-Based Emollient and Impact on Diapered Skin Erythema, Pediatr Dermatol 2025;42(3):532-538 — RCT n=271 infants, shea-butter diaper reduced dermatitis
Burnett CL, Bergfeld WF, Belsito DV, et al. Safety Assessment of Butyrospermum parkii (Shea)-Derived Ingredients as Used in Cosmetics. Cosmetic Ingredient Review Expert Panel Final Report.
Verallo-Rowell VM, Katalbas SS, Pangasinan JP. Natural (Mineral, Vegetable, Coconut, Essential) Oils and Contact Dermatitis. Curr Allergy Asthma Rep. 2016;16(7):51. — discussing shea butter unsaponifiable fraction NF-kB inhibition and dermatologic use.
A lightweight oil that mimics what your skin already makes. Softens and seals in hydration without feeling greasy.
Wolosik K et al., Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast, Molecules 2025;30(9):1964 — low-dose squalane (0.005-0.015%) restored collagen biosynthesis and wound healing in UVA-exposed human dermal fibroblasts
Morgan AB et al., Explicating the multifunctional roles of tocotrienol and squalene in promoting skin health, Skin Health and Disease 2024;4(5):e448 — squalene/squalane promotes skin health via antioxidant, hydrating, emollient, anti-inflammatory mechanisms
Fiume M et al., Safety Assessment of Squalane and Squalene as Used in Cosmetics, International Journal of Toxicology 2023;42(3_suppl):107S-109S — CIR expert-panel assessment concluding squalane is safe as a cosmetic ingredient
Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.
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