Skip to main content
Shop Neutrogena Collagen Bank 15% Vitamin C Serum
Serum★ Popular
Neutrogena

Collagen Bank 15% Vitamin C Serum

~$13.99· 0.5 fl oz
RadianceDark spotsFine lines & firmness

What it's good for

Key actives from our research database. Click any to read the full evidence dossier.

  • Vitamin CStrong evidenceFull dossier ↗

    Brightens dull skin and helps fade dark spots. Also defends against everyday UV and pollution damage when worn under sunscreen.

    Good for: Brightening, Antioxidant

  • PHAModerate evidenceFull dossier ↗

    The mildest exfoliating acid. Refines texture and hydrates at the same time, and it's sensitive-skin friendly.

    Good for: Exfoliating, Hydrating

New to this? Patch test on your inner arm for 24 to 48 hours before applying to your face. If you have sensitive skin or rosacea, start 2 to 3 times per week and build up slowly.

Evidence behind the ingredients

Real citations from our research database, one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

Vitamin CStrong evidence15 citations

Brightens dull skin and helps fade dark spots. Also defends against everyday UV and pollution damage when worn under sunscreen.

Krutmann J et al. PINGing Sunshine: A Review of the Evidence for Adding Non-Filtering Photoprotective Ingredients to Sunscreens. Photodermatol Photoimmunol Photomed. 2025;41(6). — Review of Photoprotective INGredients (PINGs); L-ascorbic acid (vitamin C) identified as a top-ranked PING demonstrating efficacy across multiple photodamage endpoints.

2025Meta-analysis (positive)PMID:41152208View source ↗

Pullar JM et al., The roles of vitamin C in skin health, Nutrients 2017;9(8):866 — concluded topical efficacy "poorly understood"; supports dietary vitamin C

2017Mechanism onlyPMID:28805671View source ↗

Lee JH et al., Effects of VitabridC12 on Skin Inflammation, Annals of Dermatology 2017

2017Mechanism onlyPMID:28966510View source ↗
PHAModerate evidence5 citations

The mildest exfoliating acid. Refines texture and hydrates at the same time, and it's sensitive-skin friendly.

Peng Y et al., Comparison of Efficacy and Willingness to a 5% Gluconolactone-Based Topical Serum and Intense Pulsed Light in Mild Erythema of Rosacea: A Paired Control Study, Journal of Cosmetic Dermatology 2025;24(3):e70025 — 5% gluconolactone serum improved erythema and moisturization over 30 days

2025Positive (efficacy)PMID:40111222View source ↗

Kantikosum K et al., The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris, Clinical Cosmetic and Investigational Dermatology 2019;12:151-161 — gluconolactone cosmeceutical added benefit on top of adapalene without hindering treatment

2019Positive (efficacy)PMID:30858720View source ↗

Edison BL et al., A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen, Cutis 2004;73(2 Suppl):14-17 — 12-week PHA regimen matched AHA antiaging benefits with significantly less stinging/burning

2004Positive (efficacy)PMID:15002657View source ↗

Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.

Layering conflicts

Ingredients in this product that can react with common actives. Avoid stacking unless noted.

  • Benzoyl peroxide breaks down vitamin C, making both less effective. Use one in the morning and the other at night.

  • Vitamin C and retinol work best at different pH levels. Use vitamin C in the morning and retinol at night.

Similar comparisons

← Back to shop

Not medical advice. GlowPal is educational. Patch-test new products and talk to a qualified healthcare professional before changing your routine, especially if you're pregnant, nursing, or have a diagnosed skin condition. See our terms.