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Shop Medik8 Hydr8™ Night - Advanced Antioxidant Cream
Moisturizer
Medik8

Hydr8™ Night - Advanced Antioxidant Cream

· 1.7 Ounce (Pack of 1)
At a glance
Routine step
Moisturizer
When
Morning and evening
Pairs well with
Panthenol, Hyaluronic Acid, Ceramides, Squalane
How to use

Apply as the last step in the evening, and before sunscreen in the morning. A fingertip-sized amount covers the face.

Ingredient research in this formula

These are ingredient-level research links, not evidence that this exact product has been clinically tested.

  • Beta-GlucanGood evidenceFull dossier

    A heavy-duty hydrator that also reduces irritation. Often called "better than hyaluronic acid" for sensitive skin.

    Good for: Hydrating, Anti-inflammatory

  • GlycerinGood evidenceFull dossier

    A workhorse hydrator that pulls water into your skin. In nearly every good moisturizer for a reason.

    Good for: Hydrating

  • ResveratrolGood evidenceFull dossier

    A grape-derived antioxidant that defends skin from daily oxidative damage and helps even out tone. Often paired with vitamins C and E in nighttime serums.

    Good for: Antioxidant, Anti-aging, Brightening

Evidence behind the ingredients

Real citations from our research database, one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

Beta-GlucanGood evidence5 citations

A heavy-duty hydrator that also reduces irritation. Often called "better than hyaluronic acid" for sensitive skin.

Feng X et al., Exploring the Properties and Application Potential of beta-Glucan in Skin Care, Food Science and Nutrition 2025;13(4):e70212: review concludes beta-glucan exhibits antioxidant, anti-inflammatory, barrier repair, and moisturizing bioactivities

2025Mechanism onlyPMID:40291929View source ↗

Kussie HC et al., Avenanthramide and beta-Glucan Therapeutics Accelerate Wound Healing Via Distinct and Nonoverlapping Mechanisms, Advances in Wound Care 2024;13(4):155-166: in vivo: beta-glucan accelerated wound closure with increased angiogenesis

2024Positive (efficacy)PMID:38299969View source ↗

Cao Y et al., Improving the outcome of treating striae gravidarum by combined therapies using topical β-glucan and 1565-nm non-ablative fractional laser, Journal of Dermatology 2022;49(9):829-836: RCT; topical beta-glucan twice daily for 12 weeks on stretch marks

2022Positive (efficacy)PMID:35570397View source ↗
GlycerinGood evidence6 citations

A workhorse hydrator that pulls water into your skin. In nearly every good moisturizer for a reason.

Danby SG et al., Different types of emollient cream exhibit diverse physiological effects on the skin barrier in adults with atopic dermatitis, Clinical and Experimental Dermatology 2022;47(6):1154-1164: glycerol+urea emollient delivered superior barrier-strengthening and irritant protection

2022Positive (efficacy)PMID:35167133View source ↗

Youssef R et al., Glycerol 85% efficacy on atopic skin and its microbiome: a randomized controlled trial, Journal of Dermatological Treatment 2021;32(7):730-736: topical glycerol 85% RCT on atopic skin

2021Positive (efficacy)PMID:31869257View source ↗

Evans NJ et al., Human axillary skin condition is improved following incorporation of glycerol into the stratum corneum from an antiperspirant formulation, Archives of Dermatological Research 2017;309(9):739-748: 4% glycerol penetrated axillary SC, reduced irritation, improved hydration

2017Positive (efficacy)PMID:28889318View source ↗
ResveratrolGood evidence6 citations

A grape-derived antioxidant that defends skin from daily oxidative damage and helps even out tone. Often paired with vitamins C and E in nighttime serums.

Shi Y, Shen C, Zhang W, Efficacy and safety of a topical skincare regimen containing CE Ferulic serum and resveratrol BE serum following ablative fractional CO2 laser treatment, Journal of the European Academy of Dermatology and Venereology 2024;38 Suppl 6:18-25: split-face RCT, resveratrol-containing serum reduced erythema and accelerated wound healing post-laser

2024Positive (efficacy)PMID:38828801View source ↗

Hecker A et al., The impact of resveratrol on skin wound healing, scarring, and aging, International Wound Journal 2022;19(1):9-28: review of resveratrol's dermatological effects on wound healing, scarring, and photoaging

2022Mechanism onlyPMID:33949795View source ↗

Lin MH et al., The bioactivities of resveratrol and its naturally occurring derivatives on skin, Journal of Food and Drug Analysis 2021;29(1):15-38: review of cutaneous resveratrol activity in photoaging, melanogenesis, and dermatitis

2021Mechanism onlyPMID:35696226View source ↗

Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.

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