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Shop Anua Heartleaf 77 Clear Pad
Treatment
Anua

Heartleaf 77 Clear Pad

· 70 pads
AcneVisible pores
At a glance
Routine step
Treatment
When
Morning and evening
Skin types
Oily, Combination, Sensitive
Pairs well with
Niacinamide, Centella Asiatica, Madecassoside, Adapalene
Use with care
3 layering conflicts, listed below
How to use

Apply a thin layer to the areas you are treating, after serums and before moisturizer. Follow the label on frequency.

This product contains an active that can irritate at first. Patch test on the inner forearm for 24 hours and start two or three times a week.

Ingredient research in this formula

These are ingredient-level research links, not evidence that this exact product has been clinically tested.

  • HeartleafGood evidenceFull dossier

    A calming K-beauty botanical that's also antibacterial, so it pairs well for acne-prone, sensitive skin.

    Good for: Anti-inflammatory, Anti-acne

  • Salicylic AcidExcellent evidenceFull dossier

    Goes into your pores and dissolves the oil and dead skin clogging them. Best for blackheads, whiteheads, and oily, acne-prone skin.

    Good for: Anti-acne, Exfoliating

New to this? Patch test on your inner arm for 24 to 48 hours before applying to your face. If you have sensitive skin or rosacea, start 2 to 3 times per week and build up slowly.

Evidence behind the ingredients

Real citations from our research database, one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

HeartleafGood evidence8 citations

A calming K-beauty botanical that's also antibacterial, so it pairs well for acne-prone, sensitive skin.

Song Z et al., Inhibition of LPS-Induced Skin Inflammatory Response and Barrier Damage via MAPK/NF-kB Signaling Pathway by Houttuynia cordata Thunb Fermentation Broth, Foods 2024

2024Mechanism onlyPMID:38790770View source ↗

Kwon N et al., Protective Effects of Fermented Houttuynia cordata Against UVA and H2O2-Induced Oxidative Stress in Human Skin Keratinocytes, Applied Biochemistry and Biotechnology 2023;195(5):3027-3046: Korean-authored; fermented H. cordata showed antioxidant and anti-inflammatory protection against UVA/H2O2 stress

2023Mechanism onlyPMID:36495375View source ↗

Rafiq S et al., Pharmacological Effects of Houttuynia cordata Thunb (H. cordata): A Comprehensive Review, Pharmaceuticals (Basel) 2022

2022Mechanism onlyPMID:36145299View source ↗
Salicylic AcidExcellent evidence9 citations

Goes into your pores and dissolves the oil and dead skin clogging them. Best for blackheads, whiteheads, and oily, acne-prone skin.

Liu Y et al., Clinical Efficacy of a Salicylic Acid-Containing Gel on Acne Management and Skin Barrier Function: A 21-Day Prospective Study, Journal of Cosmetic Dermatology 2025;24(7):e70353: salicylic acid gel reduced acne lesions, regulated sebum, improved hydration and barrier function

2025Positive (efficacy)PMID:40682377View source ↗

Ye R et al., 2% supramolecular salicylic acid hydrogel vs. adapalene gel in mild to moderate acne vulgaris: multicenter, randomized, evaluator-blind, parallel-controlled trial, Journal of Cosmetic Dermatology 2024;23(6):2125-2134: 2% SSA hydrogel was equally effective as adapalene gel for mild-to-moderate acne

2024Positive (efficacy)PMID:38590107View source ↗

Brumley C et al. Allergic contact dermatitis to salicylic acid: A case series of relevant sensitization. Contact Dermatitis. 2024;91(2):133-138. doi:10.1111/cod.14573: Case series of 489 patch-tested patients (2020-2024): 21 positive reactions to salicylic acid. Documents that ACD to SA is likely underreported; testing at 5% concentration feasible.

2024Safety assessmentPMID:38686774View source ↗

Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.

Layering conflicts

Ingredients in this product that can react with common actives. Avoid stacking unless noted.

  • Retinol + salicylic acid can over-exfoliate and damage the barrier. Alternate nights.

  • Tretinoin + salicylic acid: major irritation risk. Strict separation required.

  • AHA + BHA stacking risks over-exfoliation. Use a pre-formulated AHA/BHA product or alternate days.

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Not medical advice. GlowPal is educational. Patch-test new products and talk to a qualified healthcare professional before changing your routine, especially if you're pregnant, nursing, or have a diagnosed skin condition. See our terms.