Shop PanOxyl 10% Benzoyl Peroxide Acne Foaming Wash Maximum Strength (5.5 oz)
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PanOxyl

10% Benzoyl Peroxide Acne Foaming Wash Maximum Strength (5.5 oz)

~$24· 5.5 oz
AcneDark spotsRadianceDryness

Evidence behind the ingredients

Real citations from our research database — one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

Benzoyl PeroxideStrong evidence5 citations

Kills the bacteria that cause inflammatory acne. The first thing to reach for when you have red, painful pimples.

Huang CY et al., Comparative Efficacy of Pharmacological Treatments for Acne Vulgaris: A Network Meta-Analysis of 221 Randomized Controlled Trials, Annals of Family Medicine 2023;21(4):358-369 — BPO combinations among most effective topical regimens for acne

2023Meta-analysis — positivePMID:37487721View source ↗

Stein Gold L et al., Efficacy and Safety of a Fixed-Dose Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel for Moderate-to-Severe Acne: A Randomized Phase II Study of the First Triple-Combination Drug, American Journal of Clinical Dermatology 2022;23(1):93-104 — triple-combination gel superior to vehicle and dyad comparators

2022Positive — efficacyPMID:34674160View source ↗

Yang Z et al., Topical benzoyl peroxide for acne, Cochrane Database of Systematic Reviews 2020;3:CD011154 — BPO modestly more effective than placebo, low-certainty evidence

2020Meta-analysis — positivePMID:32175593View source ↗
GlycerinModerate evidence4 citations

A workhorse hydrator that pulls water into your skin. In nearly every good moisturizer for a reason.

Danby SG et al., Different types of emollient cream exhibit diverse physiological effects on the skin barrier in adults with atopic dermatitis, Clinical and Experimental Dermatology 2022;47(6):1154-1164 — glycerol+urea emollient delivered superior barrier-strengthening and irritant protection

2022Positive — efficacyPMID:35167133View source ↗

Evans NJ et al., Human axillary skin condition is improved following incorporation of glycerol into the stratum corneum from an antiperspirant formulation, Archives of Dermatological Research 2017;309(9):739-748 — 4% glycerol penetrated axillary SC, reduced irritation, improved hydration

2017Positive — efficacyPMID:28889318View source ↗

Fluhr JW et al., Glycerol and the skin: holistic approach to its origin and functions, British Journal of Dermatology 2008;159(1):23-34 — improves xerosis and barrier function

2008Positive — efficacyPMID:18510666View source ↗
Glycolic AcidStrong evidence6 citations

Exfoliates the surface of your skin to smooth rough texture and fade dullness. The strongest of the AHAs, so start slow.

Liu H et al., Topical agents for acne (covers AHA / fruit-acid arm), Cochrane Database of Systematic Reviews 2020;5:CD011368 — conclusion: clinical benefit is unclear

2020Meta-analysis — mixedPMID:32356369View source ↗

Sarkar R et al., Comparative Evaluation of Efficacy and Tolerability of Glycolic Acid, Salicylic-Mandelic Acid, and Phytic Acid Combination Peels in Melasma, Dermatologic Surgery 2016;42(3):384-391 — 35% glycolic acid and salicylic-mandelic peels equally effective and safe for melasma in Indian skin

2016Positive — efficacyPMID:26859648View source ↗

Kubiak M et al., Evaluation of 70% glycolic peels versus 15% trichloroacetic peels for the treatment of photodamaged facial skin in aging women, Dermatologic Surgery 2014;40(8):883-891 — both peels improved photodamaged skin; glycolic acid showed faster hydration recovery

2014Positive — efficacyPMID:25068547View source ↗
+3 more ingredients
Lactic AcidStrong evidence5 citations

A gentler exfoliator that also hydrates as it works. Good entry point if you have sensitive skin and want to try acids.

Fanning N et al., Treatment of mild-to-moderate facial cutaneous aging using a combination peel containing 6% trichloroacetic acid and 12% lactic acid, Journal of Cosmetic Dermatology 2023;22(11):3033-3041 — three monthly peels significantly improved clarity, pigmentation, fine lines, roughness in 32 subjects

2023Positive — efficacyPMID:37227430View source ↗

Tang SC, Yang JH, Dual effects of alpha-hydroxy acids on the skin, Molecules 2018;23(4):863 — effect concentration-dependent

2018Positive — efficacyPMID:29642579View source ↗

Babilas P et al., Cosmetic and dermatologic use of alpha hydroxy acids, JDDG: Journal der Deutschen Dermatologischen Gesellschaft 2012 — supports AHAs including lactic acid for photoaging, pigmentation, and barrier effects

2012Meta-analysis — positivePMID:22916351View source ↗
Sodium PCAModerate evidence4 citations

Replenishes one of the actual humectant molecules your own skin makes. Levels drop in eczema and with age, so topping it up genuinely helps dry, dehydrated, or atopic-prone skin feel less tight.

Novel design of pyrrolidonecarboxylic acid and sodium dilauramidoglutamide lysine complex for targeted drug delivery to human stratum corneum, International Journal of Pharmaceutics 2025

2025Mechanism onlyPMID:40187708View source ↗

Baldwin H, Del Rosso J, Going Beyond Ceramides in Moisturizers: The Role of Natural Moisturizing Factors, Journal of Drugs in Dermatology 2024 — review establishing PCA (pyrrolidone carboxylic acid) as a core skin natural moisturizing factor alongside amino acids, urea, lactate, and electrolytes; essential to barrier function and xerosis treatment

2024Mechanism onlyPMID:38834224View source ↗

Li L et al., Association Between Skin Acid Mantle, Natural Moisturizing Factors, and Antibacterial Activity Against S. aureus in the Stratum Corneum, Clinical Cosmetic and Investigational Dermatology 2023 — PCA and urocanic acid as NMF components contribute to skin antibacterial defense; 1-unit pH drop = 68.1% S. aureus cell death

2023Mechanism onlyPMID:37378303View source ↗
Titanium DioxideStrong evidence7 citations

Another physical sunscreen that blocks UV. Often paired with zinc oxide for full sun protection.

Polena H et al., Comparison of Visible Light-Protective Tinted Sunscreen to Untinted Sunscreen to Protect Melasma Patients During Summer: A Prospective Randomized Investigator-Blinded Study, Journal of Cosmetic Dermatology 2025;24(10):e70450 — pigmentary titanium dioxide + iron oxide tinted sunscreen significantly improved pigmentation uniformity between melasma-affected and unaffected skin vs untinted (∆L*, ∆ITA°, ∆E significantly reduced; not in untinted group)

2025Positive — efficacyPMID:41014037View source ↗

SCCS Scientific Advice on Titanium Dioxide (TiO2) (CAS/EC 13463-67-7/236-675-5, 1317-70-0/215-280-1, 1317-80-2/215-282-2), SCCS/1661/23

2024Safety assessmentSCCS/1661/23View source ↗

Ezekwe N et al., Evaluation of the protection of sunscreen products against long wavelength ultraviolet A1 and visible light-induced biological effects, Photodermatology, Photoimmunology & Photomedicine 2024;40(1):e12937 — the titanium dioxide 11% + iron oxide tinted product gave statistically significantly less erythema (IGA, Δoxyhemoglobin, Δa*) and less pigmentation at all time points vs unprotected irradiated skin

2024Positive — efficacyPMID:38069506View source ↗

Sources: PubMed · KCI · J-Stage · CNKI · Wanfang · SFD · MFDS · Cochrane · SCCS · CIR. Every entry points to a specific document. See methodology for what each outcome label means.

Layering conflicts

Ingredients in this product that can react with common actives. Avoid stacking unless noted.

  • Retinol + glycolic acid is a classic barrier-buster. Use on different nights.

  • Tretinoin + glycolic acid causes significant barrier disruption. Never layer.

  • Vitamin Cmedium

    Benzoyl peroxide breaks down vitamin C, making both less effective. Use one in the morning and the other at night.

  • Adapalenemedium

    Adapalene + glycolic acid can over-exfoliate. Alternate nights.

  • AHA + BHA stacking risks over-exfoliation. Use a pre-formulated AHA/BHA product or alternate days.

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