Shop medicube Salmon DNA PDRN Pink Collagen Jelly Gel Mask Single 28g
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Salmon DNA PDRN Pink Collagen Jelly Gel Mask Single 28g

~$18· 28g
Dark spotsFine lines & firmnessDrynessRadiance

Evidence behind the ingredients

Real citations from our research database — one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

PolydeoxyribonucleotideModerate evidence4 citations

The "salmon DNA" trending in K-beauty and Korean clinics. Strong wound-healing pedigree translated into anti-aging. Speeds repair after lasers/microneedling, smooths fine lines, and brightens. Often layered with vitamin C and niacinamide. Worth knowing: salmon- or trout-derived PDRN has much stronger clinical evidence than plant ("phyto") PDRN, and the dose matters more than the marketing — favor products that list a real PDRN concentration (roughly 1,000+ ppm) over big headline numbers on plant-derived versions.

Lee D et al., Skin Regeneration and Barrier-Improvement Efficacy of Polydeoxyribonucleotide Isolated from Panax Ginseng Adventitious Root, Molecules 2023;28(21):7240 — plant-derived PDRN promoted keratinocyte/fibroblast proliferation and strengthened barrier function

2023Mechanism onlyPMID:37959659View source ↗

Lee S, Won KH et al., A Mixture of Topical Forms of Polydeoxyribonucleotide, Vitamin C, and Niacinamide Attenuated Skin Pigmentation and Increased Skin Elasticity by Modulating Nrf2, Molecules 2022;27(4):1276 — topical PDRN + Vit C + niacinamide reduced melanin and improved elasticity in UV-B model, comparable to hydroquinone

2022Positive — efficacyPMID:35209068View source ↗

Squadrito F et al., Polydeoxyribonucleotide: A Promising Biological Platform to Accelerate Impaired Skin Wound Healing, Pharmaceuticals (Basel) 2021;14(11):1103 — review documenting PDRN activation of adenosine A2A receptors, VEGF release, and accelerated wound healing across diabetic, thermal, and ischemic models

2021Mechanism onlyPMID:34832885View source ↗
Vitamin CStrong evidence14 citations

Brightens dull skin and helps fade dark spots. Also defends against everyday UV and pollution damage when worn under sunscreen.

Pullar JM et al., The roles of vitamin C in skin health, Nutrients 2017;9(8):866 — concluded topical efficacy "poorly understood"; supports dietary vitamin C

2017Mechanism onlyPMID:28805671View source ↗

Lee JH et al., Effects of VitabridC12 on Skin Inflammation, Annals of Dermatology 2017

2017Mechanism onlyPMID:28966510View source ↗

MFDS Approved Functional Cosmetic Active — Ascorbic Acid and derivatives (whitening). Korean Ministry of Food and Drug Safety, Cosmetic Functional Active Ingredient List — L-ascorbic acid and stabilized derivatives (Magnesium Ascorbyl Phosphate, Ethyl Ascorbic Acid, Sodium Ascorbyl Phosphate) are approved whitening actives in the Korean Functional Cosmetics Codex; authorized concentrations documented in Jeon JS et al., International Journal of Cosmetic Science 2016;38(3):286-93 (PMID:26564311)

2016Regulatory approvalMFDS:AscorbicAcid-WhiteningView source ↗
NiacinamideStrong evidence11 citations

A multitasker that calms redness, evens out skin tone, and helps oily skin balance out. One of the safest do-a-little-of-everything ingredients.

Moro F et al., Skin Cancer Prevention and Antiaging: Role of Nicotinamide, International Journal of Molecular Sciences 2026

2026Mechanism onlyPMID:42278444View source ↗

Passeron T et al., An Investigator-Blinded, Randomized Trial of a Broad-Spectrum Sunscreen Containing Sclareolide and Niacinamide, Dermatology and Therapy (Heidelberg) 2026

2026Positive — efficacyPMID:41240206View source ↗

Vergilio MM et al., Topical Formulation with Niacinamide Combined with 5 MHz Ultrasound for Improving Skin Ageing, Current Medicinal Chemistry 2025

2025Positive — efficacyPMID:39171587View source ↗
+3 more ingredients
ArgirelineModerate evidence4 citations

Sometimes called "topical Botox," it's a peptide that subtly reduces the depth of expression lines around the eyes and forehead when used daily over months. Mild effect, but real.

Zhu M et al., The effect of a serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate and gluconolactone on skin biomarkers, wrinkles and skin texture: ex vivo and clinical studies, International Journal of Cosmetic Science 2026 — two clinical trials (n=50, n=42) showed 35-69% static wrinkle improvement and significant elastic fiber and collagen biomarker increases at 12 weeks

2026Positive — efficacyPMID:41668671View source ↗

Zdrada-Nowak J, Surgiel-Gemza A, Szatkowska M, Acetyl Hexapeptide-8 in Cosmeceuticals: A Review of Skin Permeability and Efficacy, International Journal of Molecular Sciences 2025

2025InconclusivePMID:40565185View source ↗

An JH, Lee HJ, Yoon MS, Kim DH, Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin, Annals of Dermatology 2019;31(3):263-271 — split-face cross-linked HA + Argireline microneedle patch improved wrinkles on Korean skin (cross-attributed; primary citation for HA id=13)

2019Positive — efficacyPMID:33911590View source ↗
Matrixyl PeptidesModerate evidence6 citations

Signals your skin to make more collagen. Quiet but real support for firmness and fine lines with consistent daily use.

Yang Y et al., Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream, Skin Research and Technology 2024;30(7):e13790 — 12-week study of active complex containing Matrixyl 3000 peptides showed significant improvement in hydration, elasticity, periorbital wrinkles

2024Positive — efficacyPMID:38932444View source ↗

Lintner K, Gerstein F, Solish N, A serum containing vitamins C and E and a matrix-repair tripeptide reduces facial signs of aging as evidenced by Primos analysis, Journal of Cosmetic Dermatology 2020;19(12):3262-3269 — matrix-repair tripeptide serum: 8-9% roughness reduction, 9% redness reduction by Primos imaging

2020Positive — efficacyPMID:33103342View source ↗

Bae JS et al., Topical application of palmitoyl-RGD reduces human facial wrinkle formation in Korean women, Archives of Dermatological Research 2017;309(8):665-671 — palmitoylated peptide reduced wrinkle formation via collagen activation and protection from degradation

2017Positive — efficacyPMID:28752204View source ↗
Copper PeptidesModerate evidence6 citations

A signal peptide that tells your skin to make more collagen and elastin. Quiet but consistent firmness support over months of daily use.

Patel MN et al., An Assessment of the Safety, Efficacy, and Tolerability of a Novel Scalp Treatment Regimen Combining a Hydroxy Acid-Based Scrub and Copper Tripeptide Serum in the Management of Seborrheic Dermatitis in Adults, Cureus 2024;16(9):e70108 — 15-day interventional study: copper tripeptide regimen reduced flaking, improved hydration in seborrheic dermatitis

2024Positive — efficacyPMID:39449909View source ↗

Jiang F et al., Synergy of GHK-Cu and hyaluronic acid on collagen IV upregulation via fibroblast and ex-vivo skin tests, Journal of Cosmetic Dermatology 2023;22(9):2598-2604 — in vitro + ex vivo: GHK-Cu + HA promoted collagen I, IV, and VII; 25.4-fold collagen IV increase in fibroblasts

2023Mechanism onlyPMID:37062921View source ↗

Dou Y et al., The potential of GHK as an anti-aging peptide, Aging Pathobiology and Therapeutics 2020;2(1):58-61 — narrative review of GHK-Cu's anti-inflammatory and tissue-remodeling mechanisms

2020Mechanism onlyPMID:35083444View source ↗

Sources: PubMed · KCI · J-Stage · CNKI · Wanfang · SFD · MFDS · Cochrane · SCCS · CIR. Every entry points to a specific document. See methodology for what each outcome label means.

Layering conflicts

Ingredients in this product that can react with common actives. Avoid stacking unless noted.

  • Benzoyl peroxide breaks down vitamin C, making both less effective. Use one in the morning and the other at night.

  • Vitamin C and retinol work best at different pH levels. Use vitamin C in the morning and retinol at night.

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