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Shop Dr.Althea 15% Niacinamide Purity Serum 30ml
Serum
Dr.Althea

15% Niacinamide Purity Serum 30ml

~$24· 30ml
AcneDark spotsRadianceVisible pores

What it's good for

Key actives from our research database. Click any to read the full evidence dossier.

  • Tea Tree OilModerate evidenceFull dossier ↗

    A natural acne spot-treatment that kills the bacteria behind red, painful pimples. Slower than benzoyl peroxide but with fewer side effects when used at 5%.

    Good for: Anti-acne, Anti-inflammatory

  • Rice Bran ExtractModerate evidenceFull dossier ↗

    A traditional Japanese brightener with built-in antioxidants. Softens, hydrates, and adds glow.

    Good for: Brightening, Antioxidant

  • NiacinamideStrong evidenceFull dossier ↗

    A multitasker that calms redness, evens out skin tone, and helps oily skin balance out. One of the safest do-a-little-of-everything ingredients.

    Good for: Brightening, Barrier repair, Anti-inflammatory

  • Vitamin EModerate evidenceFull dossier ↗

    A workhorse antioxidant that defends your skin from daily oxidative damage. Pairs especially well with vitamin C, and it's in nearly every good moisturizer for a reason.

    Good for: Antioxidant

Evidence behind the ingredients

Real citations from our research database, one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

Tea Tree OilModerate evidence6 citations

A natural acne spot-treatment that kills the bacteria behind red, painful pimples. Slower than benzoyl peroxide but with fewer side effects when used at 5%.

Najafi-Taher R et al., A topical gel of tea tree oil nanoemulsion containing adapalene versus adapalene marketed gel in patients with acne vulgaris: a randomized clinical trial, Archives of Dermatological Research 2022;314(7):673-679 — RCT showed tea tree oil + adapalene nanoemulsion gel produced significantly better reduction in total, inflammatory and non-inflammatory acne lesions than standard adapalene

2022Positive (efficacy)PMID:34251536View source ↗

Zambello A et al. Tea tree oil contact sensitization in children. Contact Dermatitis. 2021;84(2):123-124. doi:10.1111/cod.13699 — Documents allergic contact dermatitis from tea tree oil exposure in pediatric patients identified through patch testing; highlights sensitization risk in children.

2021Safety assessmentPMID:32885466View source ↗

Malhi HK, Tu J, Riley TV, Kumarasinghe SP, Hammer KA, Tea tree oil gel for mild to moderate acne; a 12 week uncontrolled, open-label phase II pilot study, Australasian Journal of Dermatology 2017;58(3):205-210

2017Positive (efficacy)PMID:27000386View source ↗
Rice Bran ExtractModerate evidence5 citations

A traditional Japanese brightener with built-in antioxidants. Softens, hydrates, and adds glow.

Zhou J et al., Exploratory study on the effect of ferulic acid derived from rice bran on dull skin, Drug Discoveries & Therapeutics 2026 (online ahead of print) — topical rice-bran ferulic acid improved facial dullness/melanin index

2026Positive (efficacy)PMID:42324157View source ↗

Zamil DH et al., Dermatological uses of rice products: Trend or true?, Journal of Cosmetic Dermatology 2022;21(11):6056-6060 — review of rice-derived ingredients with antiaging, anti-inflammatory, brightening, photoprotective effects

2022Mechanism onlyPMID:35587098View source ↗

Miyasaka K et al., Anti-melanogenic effects of glucosylceramides and elasticamide derived from rice oil by-products in melanoma cells, melanocytes, and human skin, Journal of Food Biochemistry 2022;46(10):e14353 — rice-derived ceramides/elasticamide suppressed UV-induced pigmentation

2022Positive (efficacy)PMID:35986572View source ↗
NiacinamideStrong evidence10 citations

A multitasker that calms redness, evens out skin tone, and helps oily skin balance out. One of the safest do-a-little-of-everything ingredients.

Moro F et al., Skin Cancer Prevention and Antiaging: Role of Nicotinamide, International Journal of Molecular Sciences 2026

2026Mechanism onlyPMID:42278444View source ↗

Passeron T et al., An Investigator-Blinded, Randomized Trial of a Broad-Spectrum Sunscreen Containing Sclareolide and Niacinamide, Dermatology and Therapy (Heidelberg) 2026

2026Positive (efficacy)PMID:41240206View source ↗

Vergilio MM et al., Topical Formulation with Niacinamide Combined with 5 MHz Ultrasound for Improving Skin Ageing, Current Medicinal Chemistry 2025

2025Positive (efficacy)PMID:39171587View source ↗
+1 more ingredient
Vitamin EModerate evidence6 citations

A workhorse antioxidant that defends your skin from daily oxidative damage. Pairs especially well with vitamin C, and it's in nearly every good moisturizer for a reason.

Neves JR et al., Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs, Journal of Cosmetic Dermatology 2022;21(10):4462-4469 — tocopherol-containing antioxidant serum reduced pollution-induced damage and improved aging signs

2022Positive (efficacy)PMID:35150043View source ↗

Warshaw EM et al., Patch Testing With Tocopherol and Tocopherol Acetate: The North American Contact Dermatitis Group Experience, 2001 to 2016, Dermatitis 2021;32(5):308-318 — 15-year NACDG data: positive patch-test reactions to tocopherol rare given widespread cosmetic use

2021Safety assessmentPMID:34238818View source ↗

Lin FH et al., Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin, Journal of Investigative Dermatology 2005;125(4):826-832 — ferulic acid + vit C + vit E combo doubled photoprotection vs C+E alone (cross-listed; same paper cited for Ferulic Acid and Vit C)

2005Positive (efficacy)PMID:16185284View source ↗

Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.

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