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Shop Dermalogica Clear Start Post Breakout Fix
Moisturizer
Dermalogica

Clear Start Post Breakout Fix

~$25· 0.5 Fl Oz (Pack of 1)

What it's good for

Key actives from our research database. Click any to read the full evidence dossier.

  • GlycerinModerate evidenceFull dossier ↗

    A workhorse hydrator that pulls water into your skin. In nearly every good moisturizer for a reason.

    Good for: Hydrating

  • HexylresorcinolModerate evidenceFull dossier ↗

    A potent dark-spot fader long favored by dermatologists. Pairs strongly with niacinamide for stubborn discoloration without the irritation of hydroquinone.

    Good for: Brightening, Antioxidant

  • Linoleic AcidModerate evidenceFull dossier ↗

    An essential fatty acid your sebum runs short on if you're acne-prone, and topping it up topically literally shrinks clogged pores. Also rebuilds the lipid mortar between skin cells. Found concentrated in safflower, hemp, and rosehip oils.

    Good for: Barrier repair, Anti-acne

  • N-AcetylglucosamineModerate evidenceFull dossier ↗

    A gentle brightener that fades dark spots while quietly boosting hydration. Pairs especially well with niacinamide.

    Good for: Brightening, Hydrating

  • Salicylic AcidStrong evidenceFull dossier ↗

    Goes into your pores and dissolves the oil and dead skin clogging them. Best for blackheads, whiteheads, and oily, acne-prone skin.

    Good for: Anti-acne, Exfoliating

  • SqualaneAnecdotal evidenceFull dossier ↗

    A lightweight oil that mimics what your skin already makes. Softens and seals in hydration without feeling greasy.

    Good for: Barrier repair, Hydrating

New to this? Patch test on your inner arm for 24 to 48 hours before applying to your face. If you have sensitive skin or rosacea, start 2 to 3 times per week and build up slowly.

Evidence behind the ingredients

Real citations from our research database, one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

GlycerinModerate evidence6 citations

A workhorse hydrator that pulls water into your skin. In nearly every good moisturizer for a reason.

Danby SG et al., Different types of emollient cream exhibit diverse physiological effects on the skin barrier in adults with atopic dermatitis, Clinical and Experimental Dermatology 2022;47(6):1154-1164 — glycerol+urea emollient delivered superior barrier-strengthening and irritant protection

2022Positive (efficacy)PMID:35167133View source ↗

Youssef R et al., Glycerol 85% efficacy on atopic skin and its microbiome: a randomized controlled trial, Journal of Dermatological Treatment 2021;32(7):730-736 — topical glycerol 85% RCT on atopic skin

2021Positive (efficacy)PMID:31869257View source ↗

Evans NJ et al., Human axillary skin condition is improved following incorporation of glycerol into the stratum corneum from an antiperspirant formulation, Archives of Dermatological Research 2017;309(9):739-748 — 4% glycerol penetrated axillary SC, reduced irritation, improved hydration

2017Positive (efficacy)PMID:28889318View source ↗
HexylresorcinolModerate evidence5 citations

A potent dark-spot fader long favored by dermatologists. Pairs strongly with niacinamide for stubborn discoloration without the irritation of hydroquinone.

Wu A, Gabriel V, Burney W, Chambers C, Pan A, Sivamani RK, Prospective, randomized, double-blind clinical study of split-body comparison of topical hydroquinone and hexylresorcinol for skin pigment appearance, Archives of Dermatological Research 2023;315(7):2095-2099 — split-body RCT, 1% hexylresorcinol equivalent to 2% hydroquinone in pigmentation reduction at 4 and 12 weeks

2023Positive (efficacy)PMID:36502500View source ↗

Shariff R et al., Superior even skin tone and anti-ageing benefit of a combination of 4-hexylresorcinol and niacinamide, International Journal of Cosmetic Science 2022;44(1):103-117

2022Positive (efficacy)PMID:34958693View source ↗

Draelos ZD, Diaz I, Cohen A, Mao J, Boyd T, A novel skin brightening topical technology, Journal of Cosmetic Dermatology 2020;19(12):3280-3285 — 12-week clinical trial (n=42) of hexylresorcinol + silymarin + vitamins C/E showed 45% improvement in brightening and improvements in evenness and fine lines

2020Positive (efficacy)PMID:32985076View source ↗
Linoleic AcidModerate evidence4 citations

An essential fatty acid your sebum runs short on if you're acne-prone, and topping it up topically literally shrinks clogged pores. Also rebuilds the lipid mortar between skin cells. Found concentrated in safflower, hemp, and rosehip oils.

Lin TK, Zhong L, Santiago JL. Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils. Int J Mol Sci. 2017;19(1):70. — reviews linoleic-acid-rich oils in barrier repair.

2017Meta-analysis (positive)PMID:29280987View source ↗

Liu M et al., Topical application of a linoleic acid-ceramide containing moisturizer exhibit therapeutic and preventive benefits for psoriasis vulgaris: a randomized controlled trial, Dermatol Ther 2015;28(6):373-82 — RCT linoleic-acid/ceramide cream improved barrier

2015Positive (efficacy)PMID:26286610View source ↗

Letawe C, Boone M, Pierard GE. Digital image analysis of the effect of topically applied linoleic acid on acne microcomedones. Clin Exp Dermatol. 1998;23(2):56-58.

1998Positive (efficacy)PMID:9692305View source ↗
+3 more ingredients
N-AcetylglucosamineModerate evidence5 citations

A gentle brightener that fades dark spots while quietly boosting hydration. Pairs especially well with niacinamide.

Schlessinger J, Green B, Edison BL, Murphy L, Sabherwal Y, A Firming Neck Cream Containing N-Acetyl Glucosamine Significantly Improves Signs of Aging on the Challenging Neck and Decolletage, Journal of Drugs in Dermatology 2016;15(1):47-52

2016Positive (efficacy)PMID:26741381View source ↗

Hwang JS, Lee HY, Lim TY, Kim MY, Yoon TJ, Disruption of tyrosinase glycosylation by N-acetylglucosamine and its depigmenting effects in guinea pig skin and in human skin, Journal of Dermatological Science 2011;63(3):199-201

2011Mechanism onlyPMID:21723097View source ↗

Kimball AB, Kaczvinsky JR, Li J, Robinson LR, Matts PJ, Berge CA, Miyamoto K, Bissett DL, Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial, British Journal of Dermatology 2010;162(2):435-41 — 10-week RCT (n=202) showed niacinamide + NAG reduced facial spots and hyperpigmentation beyond SPF 15 alone

2010Positive (efficacy)PMID:19845667View source ↗
Salicylic AcidStrong evidence9 citations

Goes into your pores and dissolves the oil and dead skin clogging them. Best for blackheads, whiteheads, and oily, acne-prone skin.

Liu Y et al., Clinical Efficacy of a Salicylic Acid-Containing Gel on Acne Management and Skin Barrier Function: A 21-Day Prospective Study, Journal of Cosmetic Dermatology 2025;24(7):e70353 — salicylic acid gel reduced acne lesions, regulated sebum, improved hydration and barrier function

2025Positive (efficacy)PMID:40682377View source ↗

Ye R et al., 2% supramolecular salicylic acid hydrogel vs. adapalene gel in mild to moderate acne vulgaris: multicenter, randomized, evaluator-blind, parallel-controlled trial, Journal of Cosmetic Dermatology 2024;23(6):2125-2134 — 2% SSA hydrogel was equally effective as adapalene gel for mild-to-moderate acne

2024Positive (efficacy)PMID:38590107View source ↗

Brumley C et al. Allergic contact dermatitis to salicylic acid: A case series of relevant sensitization. Contact Dermatitis. 2024;91(2):133-138. doi:10.1111/cod.14573 — Case series of 489 patch-tested patients (2020-2024): 21 positive reactions to salicylic acid. Documents that ACD to SA is likely underreported; testing at 5% concentration feasible.

2024Safety assessmentPMID:38686774View source ↗
SqualaneAnecdotal evidence5 citations

A lightweight oil that mimics what your skin already makes. Softens and seals in hydration without feeling greasy.

Wolosik K et al., Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast, Molecules 2025;30(9):1964 — low-dose squalane (0.005-0.015%) restored collagen biosynthesis and wound healing in UVA-exposed human dermal fibroblasts

2025Mechanism onlyPMID:40363772View source ↗

Morgan AB et al., Explicating the multifunctional roles of tocotrienol and squalene in promoting skin health, Skin Health and Disease 2024;4(5):e448 — squalene/squalane promotes skin health via antioxidant, hydrating, emollient, anti-inflammatory mechanisms

2024Mechanism onlyPMID:39355739View source ↗

Fiume M et al., Safety Assessment of Squalane and Squalene as Used in Cosmetics, International Journal of Toxicology 2023;42(3_suppl):107S-109S — CIR expert-panel assessment concluding squalane is safe as a cosmetic ingredient

2023Safety assessmentPMID:37752766View source ↗

Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.

Layering conflicts

Ingredients in this product that can react with common actives. Avoid stacking unless noted.

  • Retinol + salicylic acid can over-exfoliate and damage the barrier. Alternate nights.

  • Tretinoin + salicylic acid — major irritation risk. Strict separation required.

  • AHA + BHA stacking risks over-exfoliation. Use a pre-formulated AHA/BHA product or alternate days.

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Not medical advice. GlowPal is educational. Patch-test new products and talk to a qualified healthcare professional before changing your routine, especially if you're pregnant, nursing, or have a diagnosed skin condition. See our terms.