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Shop Shiseido Benefiance Wrinkle Smoothing Eye Cream
Treatment
Shiseido

Benefiance Wrinkle Smoothing Eye Cream

~$53.6· 15ml
Fine lines & firmnessDryness

What it's good for

Key actives from our research database. Click any to read the full evidence dossier.

  • SqualaneAnecdotal evidenceFull dossier ↗

    A lightweight oil that mimics what your skin already makes. Softens and seals in hydration without feeling greasy.

    Good for: Barrier repair, Hydrating

  • Matrixyl PeptidesModerate evidenceFull dossier ↗

    Signals your skin to make more collagen. Quiet but real support for firmness and fine lines with consistent daily use.

    Good for: Anti-aging

Evidence behind the ingredients

Real citations from our research database, one per tracked active in this product. Click any ingredient name to read its full evidence dossier.

SqualaneAnecdotal evidence5 citations

A lightweight oil that mimics what your skin already makes. Softens and seals in hydration without feeling greasy.

Wolosik K et al., Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast, Molecules 2025;30(9):1964 — low-dose squalane (0.005-0.015%) restored collagen biosynthesis and wound healing in UVA-exposed human dermal fibroblasts

2025Mechanism onlyPMID:40363772View source ↗

Morgan AB et al., Explicating the multifunctional roles of tocotrienol and squalene in promoting skin health, Skin Health and Disease 2024;4(5):e448 — squalene/squalane promotes skin health via antioxidant, hydrating, emollient, anti-inflammatory mechanisms

2024Mechanism onlyPMID:39355739View source ↗

Fiume M et al., Safety Assessment of Squalane and Squalene as Used in Cosmetics, International Journal of Toxicology 2023;42(3_suppl):107S-109S — CIR expert-panel assessment concluding squalane is safe as a cosmetic ingredient

2023Safety assessmentPMID:37752766View source ↗
Matrixyl PeptidesModerate evidence6 citations

Signals your skin to make more collagen. Quiet but real support for firmness and fine lines with consistent daily use.

Yang Y et al., Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream, Skin Research and Technology 2024;30(7):e13790 — 12-week study of active complex containing Matrixyl 3000 peptides showed significant improvement in hydration, elasticity, periorbital wrinkles

2024Positive (efficacy)PMID:38932444View source ↗

Aruan RR et al., Double-blind, Randomized Trial on the Effectiveness of Acetylhexapeptide-3 Cream and Palmitoyl Pentapeptide-4 Cream for Crow's Feet, Journal of Clinical and Aesthetic Dermatology 2023;16(2):37-43 — RCT of topical palmitoyl pentapeptide-4 (Matrixyl) for periorbital wrinkles

2023Positive (efficacy)PMID:36909866View source ↗

Imhof L, Leuthard D, Topical Over-the-Counter Antiaging Agents: An Update and Systematic Review, Dermatology 2021;237(2):217-229 — SR covering topical antiaging peptides

2021Meta-analysis (positive)PMID:32882685View source ↗

Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.

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