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Ingredients Brightening Phytic Acid
96Py
Tier · Moderate evidence
Brightening · Antioxidant · Exfoliating

Phytic Acid

INCI: Phytic Acid · Also called: IP-6, Inositol Hexaphosphate, Inositol Hexakisphosphate

A plant-derived acid that blocks the enzyme your skin uses to make pigment, fading dark spots and post-acne marks. Clinical trials show it measurably reduces hyperpigmentation and improves skin luminosity, with significantly less irritation than stronger AHAs. A good option for sensitive skin that still wants a brightening acid.

For your skin

A plant-derived acid that blocks the enzyme your skin uses to make pigment, fading dark spots and post-acne marks. Clinical trials show it measurably reduces hyperpigmentation and improves skin luminosity, with significantly less irritation than stronger AHAs. A good option for sensitive skin that still wants a brightening acid.

Want the science? Keep reading ↓

Mechanism of action

Phytic acid (inositol hexaphosphate) chelates the copper ions at tyrosinase's active site, reducing melanin synthesis. Simultaneously it binds transition metals that catalyse free-radical lipid peroxidation, acting as a chelating antioxidant. As a mild polyhydroxy-acid-adjacent molecule it also loosens corneocyte cohesion at the stratum corneum surface, providing gentle exfoliation without the low-pH irritation associated with glycolic or lactic acids.

Why we tier this moderate

3 cited papers across 3 countries. The mechanism is well-described and there's at least one controlled trial in the literature, but we tier this Moderate rather than Strong to stay honest about how many specific papers we cite directly.

1
International
1
United States
1
India

Cited research

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Markiewicz-Tomczyk A et al., Clinical Evaluation of Anti-Aging Effects of Combined Therapy - Azelaic Acid, Phytic Acid, and Vitamin C Applied Layer by Layer in Females, Journal of Cosmetic Dermatology 2022

2022Positive (efficacy)PMID:36056802View source ↗
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Houshmand EB. Effect of glycolic acid, phytic acid, soothing complex containing emulsion on hyperpigmentation and skin luminosity: a clinical evaluation. J Cosmet Dermatol. 2021;20(3):776-780.

2021Positive (efficacy)PMID:33458927View source ↗
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Sarkar R et al. Comparative Study of 35% Glycolic Acid, 20% Salicylic-10% Mandelic Acid, and Phytic Acid Combination Peels in the Treatment of Active Acne and Postacne Pigmentation. J Cutan Aesthet Surg. 2019;12(3):158-163.

2019Positive (efficacy)PMID:31619887View source ↗

Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.