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Ingredients Barrier repair Lanolin
92Ln
Tier · Moderate evidence
Barrier repair · Hydrating

Lanolin

INCI: Lanolin · Also called: Wool Wax, Wool Grease, Anhydrous Lanolin

Sheep-derived wax esters that mirror the molecules in your own skin lipids. Deeply conditions and softens dry, chapped skin like rough hands and damaged lips, with multiple positive RCTs behind it. Note: classic but real allergen, so patch-test if you have a wool/Balsam-of-Peru history.

For your skin

Sheep-derived wax esters that mirror the molecules in your own skin lipids. Deeply conditions and softens dry, chapped skin like rough hands and damaged lips, with multiple positive RCTs behind it. Note: classic but real allergen, so patch-test if you have a wool/Balsam-of-Peru history.

Want the science? Keep reading ↓

Mechanism of action

Complex wax-ester mixture from sheep sebaceous secretions whose chain-length distribution closely matches human stratum corneum lipids. Forms a semi-occlusive layer that holds twice its weight in water and integrates into the intercellular lipid lamellae rather than sitting on the surface like petrolatum.

Why we tier this moderate

5 cited papers across 3 countries. The mechanism is well-described and there's at least one controlled trial in the literature, but we tier this Moderate rather than Strong to stay honest about how many specific papers we cite directly.

2
United States
2
International
1
European Union

Cited research

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CIR Expert Panel. Amended Safety Assessment of Lanolin and Lanolin-Derived Ingredients as Used in Cosmetics. Cosmetic Ingredient Review Final Report. (Original 1980; reaffirmed 2005; updated 2024).

2024Safety assessmentCIR-Lanolin-2024View source ↗
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Peric O, Pavicic Bosnjak A, Mabic M, Tomic V. Comparison of Lanolin and Human Milk Treatment of Painful and Damaged Nipples: A Randomized Control Trial. J Hum Lact. 2023;39(2):310-319.

2023Positive (efficacy)PMID:36401521View source ↗
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Vieira F, Mota DDCF, Castral TC, Guimaraes JV, Salge AKM, Bachion MM. Effects of Anhydrous Lanolin versus Breast Milk Combined with a Breast Shell for the Treatment of Nipple Trauma and Pain During Breastfeeding: A Randomized Clinical Trial. J Midwifery Womens Health. 2017;62(5):572-579.

2017Positive (efficacy)PMID:28887855View source ↗
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Kiechl-Kohlendorfer U et al., The effect of daily treatment with an olive oil/lanolin emollient on skin integrity in preterm infants: a randomized controlled trial, Pediatr Dermatol 2008;25(2):174-8 — RCT olive-oil/lanolin daily infant skin care

2008Positive (efficacy)PMID:18429773View source ↗
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Jennings MB et al., A double-blind clinical trial comparing the efficacy and safety of pure lanolin versus ammonium lactate 12% cream for the treatment of moderate to severe foot xerosis, Cutis 2003;71(1):78-82 — DB RCT, lanolin for nipple pain/healing

2003Positive (efficacy)PMID:12553635View source ↗

Sources: 10 clinical journals and regulatory databases across the US, EU, Korea, Japan, and China. Every entry points to a specific document. See methodology for the full list and what each outcome label means.